...Sirisha Kundrapu; Hollie M. Reeves; Robert W. Maitta Absolute immature platelet counts (A-IPC) aid in diagnosis and treatment follow-up in thrombotic thrombocytopenic purpura (TTP). A-IPC was used to follow a patient on mycophenolate mofetil (MMF) maintenance therapy treated with a prolonged...

...Mesut Göçer; Utku Iltar; Fatma Aykaş; Vedat Aslan; İlknur Nizam; Mehmet Çelik; Erdal Kurtoğlu The vast majority of cases of thrombotic thrombocytopenic purpura (TTP) are the result of acquired antibodies which inhibit the activity of the ADAMTS13 enzyme. Acquired TTP is more frequently seen...

...A.M. Al-Awadhi; M.M. Jadaon; H.A. Al-Jafar; H.J. Al-Wazzan Background/Aims: While deficiency of a disintegrin and metalloprotease with thrombospondin-1-like domains (ADAMTS-13) was reported as the basis for the pathogenesis of thrombotic thrombocytopenic purpura (TTP), low levels have also been...

...Enzo Fagiolo A typical case of thrombotic thrombocytopenic purpura (TTP) with fatal course characterized by hemolytic anemia, thrombocytopenia and leukopenia with neutropenia is described. An autoimmune process against blood cells is proved by the presence of autoantibodies of the immunochemical...

...Chun Yang; Murray Nussbaum; Hydow Park A 24-year-old Chinese female developed fever, fluctuating neurological and renal manifestations, microangiopathic hemolytic anemia, and thrombocytopenia during the 11th week of her first pregnancy. Therapy for thrombotic thrombocytopenic purpura (TTP...

...Dan Aderka; Meir Djaldetti; Yehuda Shoenfeld; Matti Shaklai; Moshe Santo; Shlomo Berliner; Abraham Weinberger; Jack Pinkhas A patient with thrombotic thrombocytopenic purpura was treated with 8 U of fresh frozen plasma, resulting in a rapid improvement in her condition and subsequently followed...

...Mario Pini; Cesare Manotti; Alessandro Megha; Tullio Poli; Raffaele Poti 2 cases of acute idiopathic thrombotic thrombocytopenic purpura are reported. Both of them were treated with plasma exchange, antiplatelet drugs and prednisolone and both completely recovered. Plasma exchange appeared...

...Yoshitoshi Itoh; Tomoyuki Taniguchi; Naoshi Takeyama; Hideki Kuriki; Takaya Tanaka A 69-year-old woman with typical thrombotic thrombocytopenic purpura is reported, who was treated successfully by plasma exchange. An initial chromosomal analysis of peripheral blood lymphocytes revealed abnormal...

...Meir Krupsky; Raanana Sarel; Nina Hurwitz; Peretz Resnitzky The association between thrombotic thrombocytopenic purpura (TTP) and autoimmune hematological conditions is reported in 2 patients. In a 35-year-old man, acute autoimmune hemolytic anemia (AIHA) was diagnosed in 1960; until 1965 he...

...Harry Staszewski; Donald Colbourn; Virginia Donovan; Harold Ludman The case history of a 71-year-old woman with three episodes of a microangiopathic hemolytic anemia over a 22-year span is detailed. During the last episode a possible response of her thrombotic thrombocytopenic purpura (TTP)-like...

...Aamer Aleem; Saleh Al-Sugair Thrombotic thrombocytopenic purpura (TTP) occurring in patients with systemic lupus erythematosus (SLE) is rare and can be difficult to diagnose because of overlapping features of the two disorders. The aim of this study is to further characterize this uncommon...

... (chronic phase) and treated with interferon-α for 13 years, developed renal failure. Renal biopsy showed thrombotic thrombocytopenic purpura, but intensive therapy including plasma exchange and steroid administration was not effective. The activity of von Willebrand factor-cleaving protease was detectable...

...L. Lacotte; A. Thierry; V. Delwail; B. Dreyfus; F. Guilhot Thrombotic thrombocytopenic purpura (TTP) and hemolytic-uremic syndrome have recently been observed in patients undergoing interferon alpha (IFN-α) therapy. However, the relationship between disease and therapy has not been established...

... for a presumptive diagnosis of thrombotic thrombocytopenic purpura (TTP). However, her condition continued to deteriorate and a determination of ADAMTS13 activity revealed that she did not have TTP. Despite similarity in clinical manifestation, microangiopathic hemolysis in patients with metastatic cancers may...

...Orhan Türken; Ahmet Öztürk; Bülent Orhan; Gökhan Kandemir; Mustafa Yaylacı Thrombotic thrombocytopenic purpura is a syndrome characterized by hemolytic anemia, thrombocytopenia, neurological symptoms, fever and renal dysfunction. Although the syndrome is usually associated with various infections...

...Daniel Morgensztern; Mohamed A. Kharfan-Dabaja; Han-Mou Tsai; Eric C.-Y. Lian Thrombotic thrombocytopenic purpura (TTP) and warm-antibody autoimmune hemolytic anemia (AIHA) are uncommon diseases. Although TTP has been increasingly described in association with autoimmune antibodies, there are very...

...Hau C. Kwaan; Leo I. Gordon Thrombotic microangiopathy, manifesting as thrombotic thrombocytopenic purpura (TTP) or hemolytic uremic syndrome, is a common complication in cancer patients. It shares the pathogenic microvascular occlusive lesion and many clinical manifestations as the classical TTP...

...O. Kolker; S. Sviri; D.M. Linton; R. Or; A. Nagler; M.Y. Shapira Recognition of thrombotic thrombocytopenic purpura (TTP)/hemolytic uremic syndrome (HUS) following bone marrow transplantation (BMT) has increased in recent years. The use of plasma exchange has greatly improved the outlook of de novo...

...E. Bar Meir; H. Amital; Y. Levy; A. Kneller; Y. Bar-Dayan; Y. Shoenfeld Thrombotic thrombocytopenic purpura (TTP) is a fatal disease characterized by widespread platelet aggregation, hemolytic anemia and fever with renal and neurological involvement. Different factors have been associated...

...Javier de la Rubia; Aurelio López; Francisco Arriaga; Ana Rosa Cid; Ana Isabel Vicente; Maria Luisa Marty; Miguel A. Sanz We describe our experience in the management of 11 consecutive patients with thrombotic thrombocytopenic purpura (TTP) treated with a combined therapy of plasma exchange (PE...