... with coagulopathy and an increased risk of thrombosis. An association between thrombin generation (TG) capacity, disease severity, and outcomes has not been well described. Methods: We assessed the correlation of TG with sequential organ failure assessment (SOFA) and sepsis-induced coagulopathy (SIC) scores...

..., instructions or products referred to in the content or advertisements. 2022 Paroxysmal nocturnal hemoglobinuria Aplastic anaemia Thrombosis Immunotherapy Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder characterized by uncontrolled terminal complement activation...

... Thrombosis Adherence Direct oral anticoagulants (DOACs) have become the mainstay of treatment for the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation (AF), since major clinical trials showed non-inferiority of DOACs as compared to vitamin K antagonists...

...Amit R. Mehta; Aron Kefela; Charina Toste; Donald Sweet Patients with immune thrombocytopenia (ITP) are at increased risk for bleeding and are paradoxically at increased risk for thrombosis. Many patients with ITP have underlying cardiovascular (CV) disease and/or other thrombotic risk factors...

...Phaedon Dimitrios Zavras; Vikas Mehta; Sanjay Goel; Kith Pradhan; Henny H. Billett Background: Increased rates of thromboembolism (TE) have been reported in patients with COVID-19, even without prior predisposition to thrombosis. Cancer patients are already predisposed to a hypercoagulable state...

... therapeutic regimens in VITT-suspected patients. Here, we report the case of a 26-year-old female patient, who developed bilateral deep vein thrombosis in the lower legs and severe thrombocytopenia after ChAdOx2 nCov-19 vaccination. After initial anticoagulation therapy regimens including fondaparinux...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Mice Viscoelastic coagulation monitor Coagulation Thrombosis...

... of this review was to discuss cytopenias caused by systemic lupus erythematosus and antirheumatic drugs, Felty’s syndrome in rheumatoid arthritis, and autoimmune hemolytic anemia, thrombosis, and thrombotic microangiopathies related to rheumatological conditions such as catastrophic antiphospholipid syndrome...

.... Protein S deficiency Thrombosis Venous thromboembolism Thrombophilia The vitamin K-dependent glycoprotein protein S (PS) is primarily synthesized in the liver, endothelium and megakaryocytes. PS comprises multiple protein domains that are formed by overall 635 amino acids and enable...

...Siriyakorn Chansai; Supan Fucharoen; Goonnapa Fucharoen; Arunee Jetsrisuparb; Worawan Chumpia Background: Thalassemia is a group of hereditary hemoglobinopathies caused by decreased or absent synthesis of α and/or β globin chains. Studies have shown that hypercoagulability and thrombosis are common...

...Margaret C. Cupit-Link; Amulya Nageswara Rao; Deepti M. Warad; Vilmarie Rodriguez Lemierre syndrome (LS) is a multisystemic infection beginning in the oropharynx and leading to thrombosis of the internal jugular vein (IJV) with septic emboli and potential thrombotic extension to the central nervous...

...A. Girolami; E. Cosi; C. Santarossa; S. Ferrari; A.M. Lombardi Objective: To evaluate the impact of an asymptomatic congenital clotting defect (FXII deficiency) versus that of a similar but symptomatic defect (FXI deficiency) on protection from thrombosis. Patients and Methods: All patients...

...Hung Chang; Ming-Chung Kuo; Lee-Yung Shih; Jin-Hou Wu; Tung-Liang Lin; Po Dunn; Tzung-Chih Tang; Yu-Shin Hung; Po-Nan Wang Patients with acute promyelocytic leukemia (APL) are prone to both bleeding and thrombosis. The bleeding complications are well known. In contrast, APL-associated thrombosis...

.... These results may seem surprising as PMP are prothrombogenic and potent stimulators of coagulation. Therefore, higher CD61+ MP in postmenopausal women would be expected, possibly explaining the increased risk of thrombotic events in this population. Indeed, patients suffering from acute deep venous thrombosis...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Polymorphism Thrombosis Tissue hypoxia Multiple organ failure Plasminogen activator inhibitor-1 In critically ill patients, various disorders can lead...

...Seitaro Kamiya; Masayori Hagimori; Masayoshi Ogasawara; Masayuki Arakawa Thrombosis is characterized by congenital and acquired procatarxis. Nattokinase inhibits thrombus formation in vitro. However, in vivo evaluation of the therapeutic efficacy of nattokinase against thrombosis remains...

... coagulation, mainly FXII. Anecdotal reports on thrombosis in patients with prekallikrein deficiency have occasionally been reported. These involved both arterial and venous thrombosis. The purpose of the present article is to analyze the stories and the clinical pictures of all 75 cases of prekallikrein...

..., A . G . P apayanms, N . E . Stathakis, G. A rapakis and C. G ardikas Medical Research Unit, 2nd Propaedeutical Medical Department of Athens University, Evangelismos Hospital, Athens Key Words. Blood coagulation Heparin Platelet function Postoperative pla­ telet changes Thrombosis Abstract...

...N.E. Stathakis; A.G. Papayannis; M. Antonopoulos; C. Gardikas A Greek family with hereditary antithrombin III (AT III) deficiency associated with venous thrombosis is reported. 5 members of the family were affected. In these patients, AT III and heparin cofactor activities were decreased...

... and smaller platelet aggregates appeared in the arterial blood. Considerably more guinea pigs died during or after the NaA infusion than after administration of NaL. The possibility that arachidonic acid and other long-chain fatty acids may play a role in the development of thrombosis and thromboembolism...