... complication in patients with the inherited hemoglobin disorders. In thalassemia, the literature is limited, and factors associated with the development of leg ulcers in hemoglobin E (HbE) beta thalassemia, the most common form of severe beta-thalassemia worldwide, have not previously been reported. Methods...

...Lalitpatch Deeruksa; Kanokwan Sanchaisuriya This community-based study investigated anemia prevalence and certain hematologic features and their possible relationships to thalassemia and iron deficiency (ID) in a population of older people in Northeastern Thailand. Participants included 319...

...Maria Elisabetta Paglietti; Stefania Satta; Maria Carla Sollaino; Susanna Barella; Arianna Ventrella; Maria Franca Desogus; Franca Rosa Demartis; Laura Manunza; Raffaella Origa Background: The increase in HbA2 is the most important parameter for the identification of thalassemia carriers. However...

...Kasama Wongprachum; Kanokwan Sanchaisuriya; Maneelay Dethvongphanh; Boualay Norcharoen; Bousanit Htalongsengchan; Virack Vidamaly; Pattara Sanchaisuriya; Supan Fucharoen; Goonnapa Fucharoen; Frank P. Schelp Background and Aims: A pilot screening program for thalassemia was initiated in the Lao...

.... Iron overload and/or its evaluation Thalassemia Beta thalassemia major Iron chelation therapy One of the challenges we face today with respect to iron chelation in thalassemia major is achieving the lowest total body iron level without incurring the side effects of overchelation [ 1...

...Vichai Atichartakarn; Suporn Chuncharunee; Napaporn Archararit; Umaporn Udomsubpayakul; Katcharin Aryurachai The relationship between asplenia and thrombophilia in β-thalassemia disease patients is not yet completely understood. One hundred and ten adult hemoglobin (Hb) E/β-thalassemia (E/β-Thal...

...Sirivara Siridamrongvattana; Nguyen Van Hoa; Kanokwan Sanchaisuriya; Nguyen Dung; Phan Thi Thuy Hoa; Pattara Sanchaisuriya; Goonnapa Fucharoen; Supan Fucharoen; Frank P. Schelp Background and Aims: Information about the extent to which anemia is related to thalassemia and iron deficiency (ID...

...Hamidreza Saber; Abdollah Banihashem; Hamidreza Saber; Shima Tavallaie; Naghmeh Mirhosseini; Majid Ghayour-Mobarhan; Gordon A.A. Ferns Objective: Determination of the serum heat shock protein 27 (Hsp27) antibody titers and prooxidant-antioxidant balance (PAB) in patients with thalassemia as markers...

...-thalassemia were determined. Anemia was defined using the WHO criteria adjusted for age and sex. Serum ferritin <15 ng/ml was considered as ID. A number of mathematical formulas derived from RBC indices were applied to screen ID among anemic individuals. Results: Anemia was found in 41.5% (95% CI = 35.1...

... patients. A high-pressure liquid chromatography system was used as screening method for structural hemoglobinopathies and for separation of hemoglobin (Hb) F and A 2 . Results: We detected 666 cases in patients of foreign origin and 308 in native Spanish patients. Thalassemias (thal) are the most frequent...

...Maria Eliana Lai; Stefania Vacquer; Maria Paola Carta; Alessandra Spiga; Pierluigi Cocco; Claudia Abete; Sandra Dessì; Antonella Mandas The purpose of this study was to focus on pathophysiological mechanisms linking β-thalassemia intermedia (β-TI) and minor (β-TMI) with cardiovascular risk. Iron...

...Anupong Pansuwan; Goonnapa Fucharoen; Supan Fucharoen; Boonmee Himakhun; Samrit Dangwiboon The prevalence of adolescent anemia, iron deficiency and thalassemia were examined in 2 provinces of northeast Thailand. Blood specimens were collected from adolescent subjects aged 15–17 years in 2 areas...

...Marina Economou; Nikoletta Printza; Aikaterini Teli; Vassiliki Tzimouli; Ioanna Tsatra; Fotis Papachristou; Miranda Athanassiou-Metaxa There are limited studies on renal involvement in β-thalassemia, mainly involving patients on deferoxamine, reporting both glomerular and tubular dysfunction...

... in patients with various underlying anemias, including β-thalassemia, myelodysplastic syndromes, sickle cell disease, aplastic anemia, and other rare anemias. In addition to reducing key indicators of total body iron levels (serum ferritin, liver iron concentration, and toxic labile plasma iron), deferasirox...

...Ayhan Okçuoglu Çavdar; Ayten Arcasoy The present study has been carried out to estimate the gene frequency of thalassemia and abnormal hemoglobins in a random Turkish population. A total of 1,000 Haemoglobin A 2 blood samples have been studied. Fifteen of 900 adults had elevated Hb A 2...

...I. Wahidijat; A.H. Markum; Z.K. Adang A comparison was made between the results of splenectomy performed on 19 children with thalassemia major, who were operated on after the signs of hypersplenism and hemosiderosis appeared, and on 25 children (11 with thalassemia Hb E disease and 14...

...Ayten Arcasoy; Ayhan O. Cavdar We have determinated serum Zn, Fe, Cu and Mg in 42 patients aging from 3 months to 22 years with homozygous β -thalassemia and thalassemia intermedia and in 36 control subjects of the same ages. Serum zinc was significantly decreased. Serum copper and iron were...

...B. Yamak; S. Özsoylu; Ç. Altay; G. Hiçsönmez; B. Say A Turkish boy with hereditary persistence of fetal hemoglobin- β -thalassemia combination is described. His Hb F was very much elevated and no Hb A could be shown in his hemolyzate. His Hb A 2 was low-normal, corresponding to the Negro...

...S. Özsoylu; G. Hiçsönmez; C. Altay A Turkish child with Hb H- β -thalassemia and a clinical picture of thalassemia major, is described. His father and brother have α - β -thalassemia with hematologic findings no more severe than would be expected if they had either trait alone, and his mother has α...

...Stefano Cutillo; Tullio Meloni The serum levels of haptoglobin (Hp) and hemopexin (Hx) have been investigated in favism and thalassemia. In 25 children with favism, Hp was absent in 22 and both Hp and Hx in 7 cases. In 45 children with Cooley’s anemia, Hp was absent in 13 and Hx in 37 cases. In 25...