...-dependent thalassaemia (NTDT) with iron excess during pre- and post-iron chelation. Methods: Subjects with NTDT, aged older than 10 years, with serum ferritin >300 ng/ml, were included. Iron chelation with deferasirox (10 mg/kg/day) was prescribed daily for 6 months. Results: Ten patients with a median...

..., immunity and chronic inflammation. A chronic vascular inflammatory state plays an important role in the pathophysiology of thalassaemia. We aimed to analyze the levels of these adipocytokines and determine any possible correlations with disease severity or vascular inflammation markers in beta-thalassaemia...

...Eugenia Prus; Eitan Fibach Background/Aims: Iron accumulation in vital organs such as heart and liver is a major pathology in β-thalassaemia. It may also affect mature RBCs and developing erythroid precursors. The cellular damage is mainly caused by the labile iron pool (LIP) and is mediated...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Cardiac complications Chelation Magnetic resonance imaging Monitoring of thalassaemia...

... along both the granulocytic and the plasmacytic line. 5 3 2009 Acta haemat. 46: 294-306 (1971) Association of Multiple Haeinatological Disorders (Acute Myeioblastic Leukaemia, Paraproteinaemia, and Thalassaemia) in a 46,XX/46,XXqi Female G. L. Castoldi, G. D. G rusovin, G. L. Scapoli and R...

...B. Seitanidis; A. Mihas; B. Angelopoulos Serum immunoglobulin (IgG, IgA, IgM) levels have been determined in 22 splenectomized and 50 nonsplenectomized patients with β -thalassaemia major. Compared with 29 control subjects, all 3 immunoglobulins were statistically increased in the two thalassaemic...

...W. Queisser; M. Betzler; H. Heimpel; E. Kleihauer Erythropoietic cell proliferation of 6 cases of different clinical states of β --thalassaemia (thal) was studied by a combined method using Feulgen-cytophotometry and autoradiography after in vitro labelling with 3 H-TdR. An abnormal distribution...

...E. Gallo; L. Pugliatti; G. Ricco; P.G. Pich; G. Pinna; U. Mazza Clinical and haematological findings of a Sardinian family are described. Three members were carriers of Hb J Sardegna, 5 were heterozygous for β -thalassaemia and 2 were double heterozygous for Hb J Sardegna and β -thalassaemia...

...N. Nagaratnam; K.A. Siripala; A.M.P. Attapatu; J.V. Undevia; P.K. Sukumaran A Sinhalese family with hereditary elliptocytosis is been described. Three of the members had thalassaemia trait and 2 had CD u e chromosome. There was no abnormality due to the elliptocytosis nor to the presence...

...C. Lyberatos; G. Chalevelakis; A. Platis; N. Stathakis; A. Panani; C. Gardikas In a series of 31 patients with heterozygous and 20 patients with homozygous β -thalassaemia the erythrocyte protoporphyrin content was found constantly raised. The difference from normal values was statistically...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Coulter counter Erythrocyte volume Screening test for thalassaemia Sideropenia Thalassaemia Acta Haemat. 48: 234-238 (1972) A Rapid Screening...

... of newborns also showed that Hb Bart’s can accompany different abnormalities of haemoglobin production, involving α-chains, β-chains as well as γ-chains. Its presence in cord blood is, therefore, not specific for α-thalassaemia. 4 3 2009 © 1973 S. Karger AG, Basel 1973 Copyright / Drug Dosage...

...Basil Angelopoulos; Kostas Vlassopoulos; Alex Kalos Purified, haemoglobin-free oxymyoglobin preparations, obtained from heart tissue of adult subjects (Mb A) were compared with myoglobin obtained from heart tissue of fetuses (Mb F) and of individuals with homozygous β -thalassaemia (Mb C...

...A. Fertakis; G. Panitsas; B. Angelopoulos Serum haemopexin levels were determined by the radial immunodiffusion method in 96 patients with β -thalassaemia major (27 after splenectomy), in 36 with sickle cell disease and in 18 with sickle cell-thalassaemia disease (4 after splenectomy). Lowering...

...S. Rahbar; M. Azizi; G. Nowzari Homozygous haemoglobin Lepore Boston disease is described in an Iranian 16-year-old boy presenting the clinical manifestations of β -thalassaemia major. The parents were related (cousins), and both carriers of Leporetrait. It seems that the symptoms are milder...

...G. Cartei; E. Dini Three young unrelated propositi had β -thalassaemia trait ( β -th-t) and chronic unconjugated hyperbilirubinaemia (UH). Red blood cell 51 Cr t/2 was slightly reduced (from 19.0 to 22.8 days), liver function and histology, and iron metabolism included ferrokinetics and iron...

...G.A. Tsistrakis; S.P. Amarantos; L.L. Konkouris A case of homozygous βδ -thalassaemia is presented with review of the literature. Homozygous βδ -thalassaemia is a haemoglobinopathy where only haemoglobin F is present, haemoglobins A and A 2 being totally absent. Patients with this kind of anomaly...

...Giorgio Maggioni; Massimo Castro; Alberto Donfrancesco; Bruno Spano; Omero Giardini Lipids, phospholipids and the fatty acids of phospholipid fractions were studied in the red cells of patients affected by thalassaemia major. As compared to normal controls, a decrease of phosphatidylserine...

...G.A. Tsistrakis; G.J. Scampardonis; J.P. Clonizakis; L.L. Concouris On the occasion of a double heterozygote case of D haemoglobinopathy / β -thalassaemia (D thalassaemia) from Epirus (Greece), a family study was performed. It comprised 18 members, belonging to 3 generations, and revealed...

...L. Vettore; M.C. De Matteis; L. Antonini In hypochromic anaemias (heterozygous β -thalassaemia and iron deficiency anaemia) lighter red cells lose more K + than heavier ones, following incubation at 37 °C for 24 h. Both in the light and heavy fractions two subpopulations of cells with different...