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Keywords: Sickle cell disease
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Journal Articles
Journal Articles
Acta Haematol (2022) 145 (1): 1–4.
Published Online: 17 September 2021
...Ana Cristina Silva-Pinto; Letícia Santos-Oliveira; Flávia Leite Souza Santos; Simone Kashima Haddad; Gil Cunha De Santis; Rodrigo do Tocantins Calado Sickle cell disease is characterized by vaso-occlusive phenomena and haemolytic anaemia. There is a significant concern that the overlap of COVID-19...
Journal Articles
Subject Area:
Hematology , Oncology
Acta Haematol (2021) 144 (2): 182–189.
Published Online: 28 September 2020
...Anwar Al-Awadhi; Adekunle Adekile; Rajaa Marouf Background: Thrombospondin 1 (TSP-1) is a multifunctional glycoprotein secreted by platelets. In sickle cell disease (SCD), TSP-1 promotes red cell adhesion to the endothelium by binding to von Willebrand factor (vWF) and inhibiting its degradation...
Journal Articles
Subject Area:
Hematology , Oncology
Acta Haematol (2021) 144 (1): 111–116.
Published Online: 13 May 2020
...Matthew S. Karafin; Pippa Simpson; Joshua J. Field Chronic pain affects 50% of adults with sickle cell disease (SCD). Although inflammation is thought to contribute to the pathogenesis of chronic pain, no studies have examined the differences in circulating cytokines between patients with SCD...
Journal Articles
Subject Area:
Hematology , Oncology
Acta Haematol (2020) 143 (2): 163–175.
Published Online: 15 July 2019
...Kate Travis; Anthony Wood; Peter Yeh; Sachin Allahabadi; Ling-Chen Chien; Sara Curtis; Allexa Hammond; Jaden Kohn; Christine Ogugbuaja; Matthew Rees; John Shumway; Vivien Sheehan Background/Aims: We surveyed sickle cell disease (SCD) patients who transitioned from pediatric care at Texas Children’s...
Journal Articles
Journal Articles
Subject Area:
Hematology , Oncology
Acta Haematol (2011) 126 (3): 157–162.
Published Online: 20 July 2011
...Oula Abdullah Najim; Mea’ad Kadhum Hassan Objectives: This prospective study was carried out to assess lactate dehydrogenase (LDH) as a biochemical marker during acute painful episode and steady state in children with sickle cell disease (SCD). Design and Methods: A prospective descriptive study...
Journal Articles
Subject Area:
Hematology , Oncology
Acta Haematol (2011) 125 (3): 145–152.
Published Online: 24 December 2010
... patients from 2 sickle cell disease referral centers during a total follow-up of 654 patient-years and total hydroxyurea exposure of 549 patient-years. Fifty-six adverse events occurred (incidence: 12%/patient-year), with leg ulcers being the most frequent. Adverse events could arise at any time and were...
Journal Articles
Journal Articles
Subject Area:
Hematology , Oncology
Acta Haematol (2010) 123 (3): 135–139.
Published Online: 21 January 2010
... 2010 Several genetic factors modulate the phenotypic expression of sickle cell disease (SCD), the most important and most-studied of which is elevated Hb F [ 12,13 ]. Hb F does not co-polymerize with Hb S and the higher its concentration, the less the chance of intravascular sickling in an Hb SS...
Journal Articles
Subject Area:
Hematology , Oncology
Acta Haematol (2009) 123 (1): 64–70.
Published Online: 02 December 2009
...Renu Gupta; Rajaa Marouf; Adekunle Adekile Low bone mineral density (BMD) is common in sickle cell disease (SCD) patients of all ages due to erythropoietic stress and consequent bone marrow hyperplasia. Kuwaiti SCD patients have a mild clinical phenotype because of their high Hb F level. There has...
Journal Articles
Subject Area:
Hematology , Oncology
Acta Haematol (2009) 122 (2-3): 174–183.
Published Online: 10 November 2009
...Patrick B. Walter; Paul Harmatz; Elliott Vichinsky This review highlights recent advances in iron metabolism that are relevant to sickle cell disease (SCD). SCD is a common hemoglobinopathy that results in chronic inflammation. Improved understanding of how iron metabolism is controlled by proteins...
Journal Articles
Subject Area:
Hematology , Oncology
Acta Haematol (2009) 122 (2-3): 165–173.
Published Online: 10 November 2009
... in patients with various underlying anemias, including β-thalassemia, myelodysplastic syndromes, sickle cell disease, aplastic anemia, and other rare anemias. In addition to reducing key indicators of total body iron levels (serum ferritin, liver iron concentration, and toxic labile plasma iron), deferasirox...
Journal Articles
Subject Area:
Hematology , Oncology
Acta Haematol (2009) 122 (1): 64–69.
Published Online: 07 October 2009
...P.P. Landburg; E. Nur; N. Maria; D.P.M. Brandjes; B.J. Biemond; J.B. Schnog; A.J. Duits Inflammation and angiogenesis are of importance in the pathophysiology of sickle cell disease (SCD). Recently, the chemokine stromal-derived factor-1 (SDF-1) has been shown to be a key mediator of angiogenesis...
Journal Articles
Subject Area:
Hematology , Oncology
Acta Haematol (1971) 45 (4): 259–265.
Published Online: 05 March 2009
...W. Akin Isaacs Fifty individuals with sickle cell disease were given either steroids (testosterone for males and progesterone for females) at a dose of 10 mg or arachis oil intramuscularly. Sickling with metabi-sulphite was assessed at daily intervals for 5 days after the administration of the drug...
Journal Articles
Subject Area:
Hematology , Oncology
Acta Haematol (1973) 50 (2): 105–111.
Published Online: 04 March 2009
... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. G-6-PD in Ghana Sickle cell disease Acta Haemat. 50: 105-111 (1973) Glucose-6-Phosphate Dehydrogenase Electrophoresis...
Journal Articles
Subject Area:
Hematology , Oncology
Acta Haematol (1973) 50 (3): 149–153.
Published Online: 04 March 2009
...A. Fertakis; G. Panitsas; B. Angelopoulos Serum haemopexin levels were determined by the radial immunodiffusion method in 96 patients with β -thalassaemia major (27 after splenectomy), in 36 with sickle cell disease and in 18 with sickle cell-thalassaemia disease (4 after splenectomy). Lowering...
Journal Articles
Subject Area:
Hematology , Oncology
Acta Haematol (1976) 56 (6): 334–337.
Published Online: 03 March 2009
... of this study. A sickle cell trait frequency of 0.123 evidenced by hemoglobin electrophoresis correlates closely with previous studies of hemoglobinopathies in Saudi Arabs. The presence of four subjects with sickle cell disease in the study group provides further evidence of the ‘benign’ nature of sickle cell...
Journal Articles
Subject Area:
Hematology , Oncology
Acta Haematol (1984) 72 (1): 61–64.
Published Online: 25 February 2009
...M.A. Zago; F.F. Costa; S.J. Ismael; L.G. Tone; C. Bottura The effects of long-term aspirin for the treatment of sickle cell disease were compared with placebo in a double-blind trial completed by 29 patients. Each patient was submitted to a 5-month period of treatment with aspirin (median dose 31...
Journal Articles
Subject Area:
Hematology , Oncology
Acta Haematol (1984) 71 (5): 299–303.
Published Online: 25 February 2009
... disease White blood cell Actahaemat. 71: 299-303(1984) © 1984 S. Karger AG. Basel 0001-5792/84/0715-0299 $ 2.75/0 Serum Cobalamin Concentration in Sickle Cell Disease (HbSS) Bola O.A. Osifo, F.A. Lukanmbi, A. Adeyokunnu Departments of Chemical Pathology and Paediatrics, College of Medicine, University...