...Daming Xu; Long Xie; Zewen Zhang; Wenjun Yu; Jinfeng Qiu; Cheng-Wei Xu; Chunling He; Xianru Xu; Xinjian Cai; Jingxing Yi; Jun Yin Background: Adult chronic idiopathic thrombocytopenic purpura (ITP) is a chronic and usually lifelong hemorrhagic disorder in which enhanced platelet destruction...

...Daming Xu; Long Xie; Zewen Zhang; Duanxu Wang; Jinfeng Qiu; Wenjun Yu; Chengwei Xu; Chunling He; Xianru Xu; Jun Yin Objective: The objective of this study was to determine the expression of G protein-coupled receptors (GPCRs) in platelets from adult patients with chronic immune thrombocytopenic...

...Yimin Zhang; Haihui Gu; Qi Chen; Ying Zhang; Hui Cheng; Jianmin Yang; Jianmin Wang; Xiaoxia Hu Background: Aggressive growth of primitive and immature cells in the bone marrow results in reductions in megakaryocyte and platelet (PLT) counts, leading to thrombocytopenia in acute myeloid leukemia...

... Liver pathology Platelets Thrombocytopenia (isolated) Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver injury worldwide [ 1 ]. It covers a wide spectrum of hepatic disorders ranging from simple steatosis and steatohepatitis (steatosis with inflammation...

... diphosphate (ADP)-induced platelet aggregation. This risk of thrombosis is further increased in MPN patients bearing the JAK2 V617F mutation. Two ADP receptors, P2Y 1 and P2Y 12 , are present on platelets. Although the pattern of defective ADP-induced platelet aggregation in MPN suggests an abnormality...

...Jianlin Qiao; Jane F. Arthur; Margaret Collecutt; Yang Shen; Fi-Tjen Mu; Michael C. Berndt; Amanda K. Davis; Robert K. Andrews; Elizabeth E. Gardiner Introduction: Ligands acting at the platelet collagen receptor, glycoprotein (GP)VI, induce intracellular FcRγ/Syk-dependent signaling pathways...

...Andreas Rank; Rienk Nieuwland; Sabine Roesner; Katharina Nikolajek; Erhard Hiller; Bettina Toth Background: Climacteric increases the risk of thrombotic events by alteration of plasmatic coagulation. Up to now, less is known about changes in platelet- (PMP) and endothelial cell-derived...

...L. Clejan; H. Menahem It was demonstrated that washed human platelets can bind minute amounts of 14 C-DNA on their surface during short-term incubation. The binding was specific and firm in the described experimental conditions. Washed platelets bound also 14 C-DNA anti-DNA antibody complexes...

...R. Coleman; M.B.H. Youdim An electron microscopic study is presented concerning unusual lamellar bodies associated with human platelets. These lamellar bodies, resembling stacks of phospholipid-like membranes, are located within vesicles, in the surface connected open canalicular system, between...

...Z. Malik; G. Agam; M. Djaldetti The hemin effect on protein synthesis of human granulocytes, lymphocytes and platelets was examined. Hemin added to culture media without serum caused a dose-dependent inhibition of protein synthesis in all three cell types. A cell-specific enhancement of protein...

...P.C. Huijgens; C.A.M. van den Berg; L.M.F.M. Imandt; M.M.A.C. Langenhuijsen In healthy persons, a daily dose of 2,000 IU of vitamin E given for 10 days does not prolong the bleeding time and has no influence on collagen- and ADP-induced platelet aggregation nor on platelet prostaglandin synthesis...

...Turay U. Yardimci; Ayla Aktulga-Gürsoy; Orhan N. Ulutin Bovine serum albumin bound 14 C-palmitic acid (BSA- 14 C-PA) is transported into platelets of normal and cirrhotic subjects by simple diffusion. Initial uptake increases linearly with the concentration of BSA- 14 C-PA in the medium. The time...

... marrow precursor cells, and the presence of ultrastructural defects in the granulocytes and platelets and on the cell surface of the erythrocytes. Experiments with vinblastine showed that this drug was capable of producing (in vitro) strikingly similar ultrastructural defects in healthy erythrocytes...

...Jack Kutti; Soodabeh Safai-Kutti; Charles G. Zaroulis; Robert A. Good The plasma levels of β -thromboglobulin ( β -TG) and platelet factor 4 (PF-4) were determined in patients with various hematologic malignancies, and the results were related to simultaneously determined venous platelet counts...

...Bharati Chatterjea; Arati Maitra; D.K. Banerjee; A.K. Basu The status of ascorbic acid was studied at the levels of platelet and leucocyte in 32 cases of iron deficiency anaemia, 35 cases of thalassaemia and 18 normal subjects. It was found that in iron deficiency anaemia, platelet ascorbic acid...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Platelets Regulation Stimulating activity Thrombocytopoiesis Acta haemat. 69: 249-253(1983) © 1983 S. Karger AG...

... and platelet behaviour. 38% showed hyperactive platelets, demonstrating either in vitro hyperaggregability, circulating platelet aggregates, or raised plasma beta-thromboglobulin levels. 36% showed abnormally raised factor VIII coagulant activity (FVIIIc) levels, though this was mainly in female patients...

...James W. Davis; Charles R. Hartman; Rebecca F. Davis; Joseph L. Kyner; Daniel Lewis, Jr.; Phyllis E. Phillips Because patients with diabetes mellitus are at increased risk for vascular disease, we suspected that they might have increased circulating platelet aggregates. Therefore, we determined...

...M. Djaldetti; P. Fishman; D. Creter; I. Notti The in vitro effect of diclofenac sodium (Voltaren) on the ultrastructure of healthy donors’ platelets was examined and compared with those induced by aspirin (ASA). In distinction to ASA, which causes loss of platelet pseudopodia, Voltaren induced...

... and platelet β tg in 74 patients with high platelet count in addition to the evaluation of platelet aggregation and platelet serotonin (5-HT) content. The determinations of platelet serotonin content and aggregation are confirmed to be useful in the differentiation between primary and secondary forms...