... inhibitor ponatinib in obtaining hematological and metabolic remission, in a patient with Philadelphia chromosome-positive de novo T-ALL and outcomes of a therapeutic strategy containing chemotherapy intensification, nelarabine, and allogeneic hematopoietic stem cell transplantation...

..., but it is unknown whether blinatumomab can be effective following failure of anti-CD19 CAR-T cell therapy. Herein, we describe a patient with Philadelphia chromosome-positive B-ALL who relapsed after CD19-directed CAR-T therapy, but subsequently responded to the combination of blinatumomab and the tyrosine kinase...

...Nina Rosa Neuendorff; Michaela Schwarz; Philipp Hemmati; Seval Türkmen; Christiane Bommer; Thomas Burmeister; Bernd Dörken; Philipp le Coutre; Renate Arnold; Jörg Westermann The presence of a Philadelphia chromosome with a corresponding BCR-ABL1 rearrangement is the hallmark of chronic myeloid...

...Byung Woog Kang; Joon Ho Moon; Yee Soo Chae; Jong Gwang Kim; Shi-Nae Kim; Sang Kyun Sohn Although a tyrosine kinase inhibitor (TKI) targeted for BCR/ABL administered in combination with chemotherapy has been established as the current first-line strategy for Philadelphia chromosome-positive acute...

..., as well as the absence of hepatosplenomegaly. The diagnosis of CML was ascertained by the presence of Philadelphia chromosome with translocation of its deleted arms on the short arms of a chromosome No. 6. The possible relationship between the chromosomal aberration and the unusual hematological...

..., instructions or products referred to in the content or advertisements. Chronic myeloid leukemia Cytogenetics Karyotype Myeloproliferative disorders Philadelphia chromosome Y chromosome Acta haemat. 57: 310-320 (1977) Loss of the Y Chromosome from Bone Marrow Cells of Males with Myeloproliferative...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Agar culture Chronic myeloid leukemia Colony cells Lymphocytes Philadelphia chromosome T lymphocytic colonies Acta haemat. 66: 174-180 (1981) Ph'-Negative T...

... Chromosomal abnormalities, additional Ph Philadelphia chromosome Acta haemat. 76: 130-135(1986) © I 986 S. Karger A G . Basel 0001-5792/86/0763-0130 $ 2.75/0 Additional Chromosomal Abnormalities to Ph during the Clinical Course in Patients with Acute Lymphoblastic Leukemia P. Carbonea, G. Barbataa, F...

...Eric Archimbaud; Christiane Charrin; Martine Ffrench; Denis Fière; Jean-Jacques Viala We report the case of a 70-year-old woman in whom Philadelphia chromosome-positive acute leukaemia occurred 12 years after radiation therapy for a carcinoma of the cervix. Morphology of the blasts...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Acute leukaemia Cell markers Cell sorter Immunogold Monosomy 7 Philadelphia chromosome Progenitor cell Original...

..., in a second transplantation in nude mice, we observed a shorter period of latency before tumor appearance (3 weeks) when compared to the initial transplantation. Chronic myeloid leukemia Philadelphia chromosome 10 01 1989 28 11 1989 20 2 2009 © 1990 S. Karger AG, Basel 1990...

... stem cell which does not involve the T lymphocyte lineage. Breakpoint cluster region Essential thrombocythaemia Philadelphia chromosome T cells 8 09 1989 28 11 1989 20 2 2009 © 1990 S. Karger AG, Basel 1990 Copyright / Drug Dosage / Disclaimer Copyright: All rights...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. bcr-abl hybrid messenger RNA Chronic myelogenous leukemia Essential thrombocythemia Philadelphia chromosome Case Report Acta Haematol 1995:94:52-54 Satoshi Hashino...

... Philadelphia chromosome-positive meta-phases) was present on at least one occasion in 9/30 (30%), a partial cytogenetic response (between 1 and 34% Philadelphia chromosome-positive metaphases) in 7/30 (23%) and a minor response in 4/30 (13%), giving an overall cytogenetic response rate of 67%. Significant side...

...Sakari Knuutila; Mikael Lindlöf; Panu E. Kovanen; Torbjörn Ramqvist; Tapani Ruutu; Leif.C. Andersson A ‘B’ cell line, originating from a patient with chronic myeloid leukemia and containing the Philadelphia chromosome, was established after Epstein-Barr virus transformation. The Philadelphia...

... breakpoint cluster region Philadelphia chromosome Testicular relapse Case Report Acta Haematol 1993;89:100-103 D.V. O Briena J.M. Craigb L.M. Seeker-Walked B.J. Boughton3 Department of Haematology, Queen Elizabeth Hospital, Edgbaston, Birmingham; Cytogenetics Laboratory, Department of Haematology...

... cause for an elevated white count and typically have an elevated leukocyte alkaline phosphatase score, hepatosplenomegaly, elevated vitamin B12 and are Philadelphia chromosome-negative. CNL has occasionally been associated with paraproteinemia or outright myeloma. Dysplastic features within...