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Keywords: PD-1
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Journal Articles

The IRE1α Endonuclease Plays a Dual Role in Regulating the XBP1/miRNA-34a Axis and PD-1 Expression within Natural Killer Cells in Hodgkin Lymphoma

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Subject Area:
High Impact Articles in Hematology , Hematology , Oncology
Karolina Bednarska, Gayathri Thillaiyampalam, Sally Mujaj, Jamie Nourse, Jay Gunawardana, Muhammed B. Sabdia, Soi C. Law, Anna Pilaar, Qingyan Cui, Lilia M. de Long, Frank Vari, Maher K. Gandhi, Alexandre S. Cristino
Journal: Acta Haematologica
Acta Haematol (2024) 147 (6): 676–691.
https://doi.org/10.1159/000536044
Published Online: 14 March 2024
... complex class I, rendering it susceptible to antitumoral immunity by natural killer (NK) cells. Despite the functional impairment of PD-1 + NK cells in HL, the underlying mechanisms of NK cell dysfunction remain unclear. Methods: This study involved 14 HL patients and SNK10/KHYG-1 cell lines to assess NK...
View articletitled, The IRE1α Endonuclease Plays a Dual Role in Regulating the XBP1/miRNA-34a Axis and PD-1 Expression within Natural Killer Cells in Hodgkin Lymphoma
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Journal Articles

Accelerated Chronic Lymphocytic Leukemia and Richter Transformation in the Era of Novel Agents

Open Access
Subject Area:
Hematology , Oncology
Ilana Levy Yurkovski, Tamar Tadmor
Journal: Acta Haematologica
Acta Haematol (2024) 147 (1): 73–83.
https://doi.org/10.1159/000533664
Published Online: 04 September 2023
... to in the content or advertisements. 2023 Richter’s transformation Accelerated chronic lymphocytic leukemia Diffuse large B-cell lymphoma Novel agents Bruton tyrosine kinase inhibitor B-cell lymphoma-2 PD-1 Chimeric antigen receptor T cell There are currently three histological and clinical...
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Journal Articles

Anti-PD-1-Targeted Therapies Focusing on Lymphatic Malignancies: Biological Rationale, Clinical Challenges and Opportunities

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Subject Area:
Hematology , Oncology
Meirav Kedmi, Abraham Avigdor, Arnon Nagler
Journal: Acta Haematologica
Acta Haematol (2015) 133 (2): 129–135.
https://doi.org/10.1159/000362151
Published Online: 16 February 2015
... in spite of maximal therapy. Both solid tumors and lymphoid malignancies develop mechanisms in order to escape destruction by the intact immune system. One such mechanism is mediated through immune checkpoints. PD-1 (programmed cell death protein-1, which is expressed on activated T and B cells, natural...
View articletitled, Anti-PD-1-Targeted Therapies Focusing on Lymphatic Malignancies: Biological Rationale, Clinical Challenges and Opportunities
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