... lymphoma with central nervous system (CNS) involvement is very poor and there is no established standard therapy. We retrospectively analyzed 18 patients (4 untreated and 14 relapsed) with systemic lymphoma with CNS involvement who received methotrexate and cytarabine-based multiagent chemotherapy...

..., i.e. 10 of 19 cases. Six showed signs of meningeal leukemia while they were in hematologic remission and the other 4 were within acute stage. Nine children were given methotrexate intrathecally as a prophylactic measure at the time when diagnosis of leukemia was confirmed, and did not suffer from...

...D. Lockner; U. Ericson To investigate the anaemia found in chronic alcoholics with liver damage, model experiments in mice were performed, lasting from 5 weeks up to 1 year. Four groups were tested obtaining tapwater (controls), 100/o alcohol, tap-water containing small amounts of methotrexate...

... crisis, i.e., those that had passed the blast stage, had exactly the same actinomycin D binding values as normal myeloid cells. After 0.5 mg/kg methotrexate, increased actinomycin D binding on the part of the entire leukaemic population was observed in one case of acute myeloblastic leukaemia...

... and after folate antagonism was produced by methotrexate administration. Incorporation of L-leucine- 14 C into β ⁰ and β S by bone marrow cells was unchanged as a result of the treatment with methotrexate, indicating that synthesis of these globin chains was not selectively affected by the drug. 4 3...

...Giovanni Luca Pagliardi; Vilma Gabutti; Felice Gavosto Kinetics of the blast populations in two cases of acute lymphoblastic leukaemia during treatment with methotrexate have been studied in vivo. Beside a striking cytocidal effect on blasts arrested in the S phase and a synchronization...

... intrathecal methotrexate (i.t. MTX). Skull radiology showed bilateral gyriform calcification of both cerebral hemispheres. Hematological relapse was first detected 5 years after diagnosis and the child died 5 months later. The most striking findings of a right frontal lobe biopsy and the postmortem...

... a considerable heterogeneity. When the supernatant was preincubated with methotrexate (MTX), the inhibition of folic acid binding was complete in some cases whereas in others it was negligible: these findings have been confirmed by studying the 3 H-MTX binding capacity by the same supernatants. In this case...

...Alois A. Gratwohl; Malcolm I. Bull; Robert G. Graw, jr.; Larry Norton; Turid Knutsen Methotrexate (MTX) followed by citrovorum factor (CVF) rescue was evaluated for its effectiveness in reducing graft-versus-host disease (GVHD) in lethally irradiated dogs transplanted with bone marrow from...

...Noriharu Sato; Osamu Takatani; Takayuki Hosoi; Naoki Shirafuji; Akio Urabe; Fumimaro Takaku Two patients with pure red cell aplasia were treated with intermittent administration of methotrexate. One who was refractory to conventional immunosuppressive therapy showed a favorable response...