... ASCT at relapse (triplet-alone) could result in comparable outcomes. Methods: This was a systematic review and meta-analysis of randomized controlled trials comparing upfront ASCT versus triplet-alone approach among myeloma patients treated with triplet therapy, which included two novel agents...

...) and unfavorable OS (HR = 1.656, 95% CI: 1.366–2.009, p = 0.000) but not with PFS (HR = 1.349, 95% CI: 0.852–2.136, p = 0.201). Conclusion: This meta-analysis demonstrated that high MVD was related to advanced disease stage and associated with unfavorable OS of NHL patients. A total of 921 literatures were...

... contradictory results regarding the impact of PNH clones on AA patients with immunosuppression treatment, and PNH clones have not been confirmed as positive predictors of response in the AA guidelines of the British Society for Standards in Haematology. Methods: We performed a meta-analysis to address...

...Pan Pan; Lijuan Wang; Yanjun Wang; Li Shen; Pingping Zheng; Chunli Bi; Anning Zhang; Yaogai Lv; Zhiqiang Xue; Mengzi Sun; Chong Sun; Jiagen Li; Lina Jin; Yan Yao Backgrounds: We performed this systematic review and meta-analysis to compare the efficacy of new-generation tyrosine kinase inhibitors...

...Yanping Shao; Wenda Luo; Haiyan Xu; Li Zhang; Qunyi Guo Introduction: This systematic review and meta-analysis aims to explore the influence of ferumoxytol versus placebo on iron deficiency anemia. Methods: We search for randomized controlled trials (RCTs) assessing the effect of ferumoxytol...

... in CR1, we performed a meta-analysis of 11 clinical studies. The outcomes included relapse-free survival (RFS), overall survival (OS), relapse rate (RR), and treatment-related mortality (TRM). Results: Compared with autoSCT, alloSCT showed better RFS, OS, and RR benefits, but higher TRM. Subgroup...

...Huihong Dou; Yuanhan Qin; Guoli Chen; Yanjun Zhao Deferasirox (DFX) has recently been used to treat thalassemia with iron overload; however, its long-term effectiveness and safety await multi-year studies. In this study, a systematic meta-analysis was performed to assess the effectiveness...

...). The purpose of this study is to provide a review and a meta-analysis of the current literature regarding the prognostic value of MVD in the overall survival (OS) of MM patients. Methods: MEDLINE was screened for studies evaluating the OS of MM patients with regard to their MVD count in BM trephine. The pooled...

... from PubMed, EMBASE, Cochrane Library, ChinaInfo and China National Knowledge Infrastructure (CNKI) databases from the inception to June 20, 2014. Thereafter, the eligible studies were selected based on the predefined criteria, and the literature quality was assessed. The meta-analysis was conducted...

... and timing of transplantation remain to be defined. We performed a systemic review and meta-analysis examining the efficacy and safety of allo-SCT for PTCL. The pooled 3-year overall survival (OS) of PTCL patients treated with allo-SCT was 49.6% (95% confidence interval, CI: 41.7-57.5%). A meta-analysis of 3...

... to in the content or advertisements. 2013 Autologous stem cell transplantation Meta-analysis Peripheral T cell lymphoma Peripheral T cell lymphoma (PTCL) is a small heterogeneous subgroup of non-Hodgkin's lymphoma (NHL).Though clinical characteristics vary with different PTCL subgroups, patients...

... epidemiologic studies were identified in PubMed and Embase to conduct a meta-analysis using STATA. Results: In the pooled analysis with multiple cancer types, patients carrying the CYP2C8 rs1934951 AA or AG genotype showed no significantly increased BONJ susceptibility compared with those carrying the wild GG...

... review and meta-analysis conducted by our group, which included RCTs assessing different regimens for GVHD prophylaxis in various hematological disorders, including aplastic anemia [ 24 ]. We demonstrated a reduction of GVHD in the MTX and CsA arm compared to CsA alone, albeit with no affect on overall...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. G-CSF GM-CSF Leukemia Lymphoma Meta-analysis Systematic review Myeloid colony-stimulating factors (M-CSFs) are a class of cytokines including granulocyte colony...

... Antifungals Antivirals Infection control Meta-analysis Prophylaxis Systematic review Although an RCT is the optimal design to assess interventions, the use of the term ‘random’ in the publication does not guarantee freedom from bias. Some trials presented as RCTs use inadequate methods...

... compared with further intensive post-remission non-myeloablative chemotherapy or no further therapy. Methods: A meta-analysis evaluating autologous SCT versus further chemotherapy or no treatment for acute myeloid leukemia (AML) in first complete remission (CR1) was completed. The search used the following...