...S.N. Wickramasinghe; Valerie Bush Bone marrow fragments from 10 patients with a megaloblastic anaemia due to vitamin B 12 or folate deficiency were studied by electron microscopy and electron microscope autoradiography. A proportion of the erythroblasts showed ultrastructural abnormalities. Some...

.... The percentage of erythroblasts with megaloblastoid changes was abnormally high. It was not increased in the cases with chromosomal abnormalities. These findings indicate that chromosomal aberrations are not prerequisites for the development of megaloblasts in AML. Furthermore, abnormalities in the DNA synthesis...

...U. Sjögren; H. Thysell Bone marrow smears from 57 patients with chronic renal failure were morphologically analysed. In 55 patients on regular haemodialysis there was a slight ‘shift to the left’ and a significant eosinophilia within the granulopoiesis concurrently with slight megaloblastic changes...