... . In the preleukaemic phase a striking proliferation defect in the early polychromatic erythroblasts was observed, consisting of an accumulation of cells in G 1 and a decreased proportion of cells in S. In the megakaryocytes low DNA values from 2c-8c as compared to 4c-32c in normal megakaryocytopoiesis, and a decreased...

...Hideo Kimura; Tohru Ohkoshi; Shin Matsuda; Tatsumi Uchida; Shigeo Kariyone Megakaryocytopoiesis in polycythemia vera (PV) was characterized by in vitro growth of marrow megakaryocytic progenitors (CFU-Meg) and quantitation of megakaryocyte numbers in marrow biopsy specimens in 14 patients with PV...

... of megakaryocytopoiesis in myeloid metaplasia. Using the periodic acid-Schiff reaction (PAS) and particularly the monoclonal antibody CD61 (Y2/51), all elements of this cell lineage including precursors could be identified. In comparison with bone marrow specimens from our file material (40 patients with OMF, 15 control...

...Kazuo Dan; Seiji Gomi; Kouiti Inokuchi; Kíyoyuki Ogata; Takashi Yamada; Ichiro Ohki; Setsuo Hasegawa; Takeo Nomura We studied the effects of interleukin-1 (IL-1) and tumor necrosis factor (TNF) on mouse megakaryocytopoiesis to evaluate the role of these cytokines in reactive thrombocytosis...

..., instructions or products referred to in the content or advertisements. Hematopoiesis Leukemia Megakaryocytopoiesis Stem cell factor Acta Haematol 1996;95:257-262 H. T. Hassan A. Zander Bone Marrow Transplantation Center, Department of Hematology and Oncology, Hamburg University Hospital Eppendorf...

... of megakaryocytopoiesis and platelet activity. The purpose of this study is to investigate the status and kinetics of IL-6 and selectins, which are involved in the platelet function, production, and immunologic functions, during the clinical course of ITP, that may be helpful for understanding the biology of the disease...