...E. van Kammen The case histories of three patients with generalized mastocytosis are presented and discussed. The first patient had extensive urticaria pigmentosa, hepatosplenomegaly, polylymphadenopathy and myelofibrosis. The best therapeutic results were obtained with prednisone in combination...

...Cem Akin Mast cell is a hematopoietic lineage dependent on Kit signaling for growth, differentiation, and survival. Mast cells are found in excessive numbers in tissues in a heterogeneous group of disorders collectively known as mastocytosis. Last decade has witnessed important advancements in our...

...Rajeev Gupta; Barbara J. Bain; Caroline L. Knight Clonal cytogenetic abnormalities similar to those observed in other haematological neoplasms are demonstrable in a proportion of patients with systemic mastocytosis and in a smaller proportion of adults with urticaria pigmentosa without apparent...