..., the precise molecular breakpoints are frequently not determined. Here we describe a rapid analysis of genetic imbalances combining fine tiling comparative genomic hybridization (FT-CGH) and ligation-mediated PCR (LM-PCR). We clarified an inv(14)(q11q32) in a case of T cell acute lymphoblastic leukaemia...

...R.P. Tarocco; A. Pileri; A. Ponzone; F. Gavosto In vitro labelling of circulating blasts with 3 H-thymidine was followed by their autotransfusion in a case of steady state acute lymphoblastic leukaemia. Labelling index and mean grain values were then determined autoradiographically at various...

...B. Hœrni; C. Vital; E. Bonnaud An individual suffering from ataxia-telangiectasia (AT) presented an acute lymphoblastic leukaemia. He comes from a family in which, in addition to the AT which affects half of his siblings, there are a consanguineous marriage and numerous cancers. In connection...

... of lymphoblastic leukaemia and in 2 of 11 cases of acute leukaemia of uncertain type. Such an exclusively granular reaction was never seen in other types of acute leukaemia. In most cases of myeloblastic, promyelocytic, myelomonocytic and monocytic leukaemia, a positive staining reaction was noted which was either...

...Giovanni Luca Pagliardi; Vilma Gabutti; Felice Gavosto Kinetics of the blast populations in two cases of acute lymphoblastic leukaemia during treatment with methotrexate have been studied in vivo. Beside a striking cytocidal effect on blasts arrested in the S phase and a synchronization...

...S.J. Ilett; J.S. Lilleyman The platelet transfusion requirements of 70 unselected children with lymphoblastic leukaemia were studied from the time of diagnosis to the achievement of complete remission, or to death if no remission was obtained. Platelets were not transfused unless clinically...

...P.J. Wyld; J.S. Lilleyman A 3-year-old child is described with an ovarian relapse arising 2 years after starting treatment for ‘common’ lymphoblastic leukaemia. This, considered with previously described cases, suggests that ovarian disease can arise as a late complication in girls without poor...