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Keywords: Iron overload
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Journal Articles
Journal Articles
Journal Articles
Subject Area:
Hematology , Oncology
Acta Haematol (2023) 146 (6): 458–464.
Published Online: 11 August 2023
... Splenectomy Iron overload Thalassemia is one of the most common monogenic genetic disorders worldwide, with a region-specific distribution that generally overlaps with areas experiencing the malaria endemic [ 1 ]. About 1–5% of the global population carries thalassemia mutations [ 2 ]. In China...
Journal Articles
Subject Area:
Hematology , Oncology
Acta Haematol (2021) 144 (3): 332–336.
Published Online: 02 October 2020
... months in grade 2; 33.2 ± 16.4%, median 144 ± 18 months in grade 1; p = 0.011); bone marrow iron overload ( p = 0.003; HR 1.7) and transfusion dependency (0.001; HR 2.6) negatively impacted on survival. We suggest that a higher grade of iron storage at diagnosis can impact on the outcome in MDS patients...
Journal Articles
Journal Articles
Journal Articles
Subject Area:
Hematology , Oncology
Acta Haematol (2016) 135 (4): 200–207.
Published Online: 28 January 2016
...Claire Sheeran; Donald K. Bowden; Sant-Rayn Pasricha; Ken Cheng; Giovanni Romanelli; Roger E. Peverill Background/Aims: Hemoglobin H (HbH) disease is associated with iron overload, but whether this results in serious cardiac or vascular sequelae is unresolved. Methods: We identified 39 adult...
Journal Articles
Subject Area:
Hematology , Oncology
Acta Haematol (2014) 131 (4): 222–226.
Published Online: 05 December 2013
... stem cell transplantation Iron overload Toxicity Iron overload, whether transfusion-related or not, is a well-documented complication of patients undergoing hematopoietic stem cell transplantation (HSCT) [ 1 ]. Nontransferrin-bound iron (NTBI) has been reported after myeloablative...
Journal Articles
Subject Area:
Hematology , Oncology
Acta Haematol (2013) 130 (2): 64–73.
Published Online: 26 August 2013
... and safety of oral iron chelators, and noninvasive techniques for the assessment of iron overload are translated into better patient outcomes. The construction of TM management guidelines facilitated the incorporation of such evidence into practice. However, as several aspects of the management of TM remain...
Journal Articles
Journal Articles
Subject Area:
Hematology , Oncology
Acta Haematol (2012) 128 (1): 28–32.
Published Online: 15 May 2012
... (exon 7, c.809A→T), a mutation previously reported only in 1 black patient with iron overload who resided in the Republic of South Africa. The present patient was also heterozygous for: heme transporter FLVCR1 novel allele P542S (exon 10, 1624C→T); FLVCR1 T544M (rs3207090); hemopexin (HPX) R371W...
Journal Articles
Journal Articles
Journal Articles
Subject Area:
Hematology , Oncology
Acta Haematol (2010) 124 (4): 191–196.
Published Online: 02 November 2010
...-thalassaemia, perhaps due to the toxic effect of iron overload on adipose tissue. Paradoxically, adiponectin levels are high and positively correlated with endothelin-1, raising questions about the pro- or anti-inflammatory role of this adipocytokine in beta-thalassaemia. 14 04 2010 3 08 2010 2...
Journal Articles
Journal Articles
Subject Area:
Hematology , Oncology
Acta Haematol (2009) 122 (2-3): 134–139.
Published Online: 10 November 2009
... therapy although a randomized trial of phlebotomy versus no treatment has never been reported. Since the discovery of the HFE gene in 1996, it has been possible to predict the risk of developing iron overload by a simple blood test to detect C282Y homozygotes of the HFE gene. The application...
Journal Articles
Subject Area:
Hematology , Oncology
Acta Haematol (1979) 61 (4): 209–215.
Published Online: 03 March 2009
... levels and unit of blood transfused on the other. The results of this study suggest that iron overload could be a cause of damage in the high frequency elements of the auditory mechanism. Intermittent hypoxia and slow 8th nerve compression due to bony hypertrophy as causes of auditory involvement...
Journal Articles
Subject Area:
Hematology , Oncology
Acta Haematol (1977) 57 (2): 96–101.
Published Online: 03 March 2009
...M. Westerhausen; G. Meuret A 71-year-old woman showed a highly unusual pattern of iron distribution in the organism which was associated with iron overload. The hallmark of this disease was an extreme hypersiderinemia, the serum iron reaching about 800 μ g/l00 ml. There was a pigment cirrhosis...
Journal Articles
Subject Area:
Hematology , Oncology
Acta Haematol (1981) 65 (1): 32–39.
Published Online: 27 February 2009
... active hepatitis, 23 with chronic persistent hepatitis, 22 with siderosis). Viral marker studies showed only 3 cases with both HBsAg and anti-HBc posiüvity in the serum, while the others had anti-HBc and anti-HBs or only anti-HBs or no B viral markers. A significantly higher iron overload was found...
Journal Articles
Subject Area:
Hematology , Oncology
Acta Haematol (1980) 64 (5): 271–275.
Published Online: 27 February 2009
... was significantly higher than normal values indicating tissue excess and came down sharply after treatment with iron. In thalassaemia, associated presumably with iron overload, ascorbic acid status of platelets was definitely lower than normal indicating tissue deficiency. Leucocytic level of ascorbic acid...