...Dmitri Guz; Anat Gafter-Gvili; Nirit Lev; Gal Sahaf Levin; Shaul Lev Background: Tocilizumab has been proposed as an effective treatment for severe COVID-19. We aimed to investigate whether tocilizumab administration is associated with increased availability of serum iron which may possibly...

...Chie Ogawa; Ken Tsuchiya; Naohisa Tomosugi; Kunimi Maeda Introduction: Hypoxia-inducible factor prolyl hydroxylase domain inhibitors (HIF-PHI) are a new treatment for renal anemia. HIF-PHI is believed to increase iron usage to improve availability of iron for erythropoiesis. Therefore...

...Thomas G. DeLoughery As the adverse effects of iron deficiency are better recognized, the use of oral and intravenous iron has increased dramatically. Oral iron is often poorly tolerated, with up to 70% or more of patients noting gastrointestinal issues; this may affect adherence to therapy...

...Oren Zusman; Osnat Itzhaki Ben Zadok; Anat Gafter-Gvili Anemia is a common finding in patients with heart failure (HF). The cause for anemia is multifactorial, with iron deficiency being the most common cause. Anemia with HF is an established predictor of morbidity and mortality. Iron deficiency...

...Jun Wang; Gabor Radics; Michael Whelehan; Aoibhe OʼDriscoll; Anne Marie Healy; John F. Gilmer; Mark Ledwidge Background: Iron food fortification and oral iron formulations are frequently limited by poor absorption, resulting in the widespread use of high-dose oral iron, which is poorly tolerated...

...Yutaka Kohgo; Akio Urabe; Yurdanur Kilinç; Leyla Agaoglu; Krzysztof Warzocha; Koichi Miyamura; Lay Cheng Lim; Sabine Glaser; Candace Wang; Wieslaw Wiktor-Jedrzejczak Iron overload in transfusion-dependent patients with rare anemias can be managed with chelation therapy. This study evaluated...

...Shing Chan; Mei-pian Chen; Jia-min Cao; Godfrey C.F. Chan; Yiu-fai Cheung Background: Increased circulating endothelial microparticles (EMPs) have been shown to associate with endothelial dysfunction. We explored the effect of iron on EMP generation by human umbilical vein endothelial cells (HUVECs...

..., instructions or products referred to in the content or advertisements. Iron overload and/or its evaluation Iron Iron absorption 15 07 2013 15 07 2013 24 9 2013 I read with interest the case report by Nicolson et al. [ 1 ] describing a patient with secondary iron overload...

... = 0.006) than TF CC subjects. Hematological parameters (RBC, RBC indices, hemoglobin, hematocrit, WBC, neutrophils, lymphocytes, platelets and erythrocyte sedimentation rate), iron, ferritin, TF saturation, C-reactive protein and CD4 count did not differ according to TF phenotype. Conclusion: Subjects...

...Maria Eliana Lai; Stefania Vacquer; Maria Paola Carta; Alessandra Spiga; Pierluigi Cocco; Claudia Abete; Sandra Dessì; Antonella Mandas The purpose of this study was to focus on pathophysiological mechanisms linking β-thalassemia intermedia (β-TI) and minor (β-TMI) with cardiovascular risk. Iron...

...Eugenia Prus; Eitan Fibach Background/Aims: Iron accumulation in vital organs such as heart and liver is a major pathology in β-thalassaemia. It may also affect mature RBCs and developing erythroid precursors. The cellular damage is mainly caused by the labile iron pool (LIP) and is mediated...

..., both of which can cause depression of erythropoietin (EPO) production and bone marrow activity. The cytokines also induce iron deficiency by both reducing gastrointestinal iron absorption and iron release from iron stores located in the macrophages and hepatocytes. Iron deficiency can cause...

...Clara Camaschella; Erika Poggiali Most types of genetic hemochromatosis are due to mutations in the HFE gene, although similar iron overload and organ damage can also result from mutations in genes other than HFE in rare types of hemochromatosis. Non- HFE hemochromatoses have been divided into two...

...Pauline Lee Iron, an essential element for life, is regulated primarily at the level of uptake, storage, and transport in order to maintain sufficient availability for normal physiology. The key protein in iron homeostasis is a 25-amino-acid peptide, hepcidin, which modulates the amount of iron...

... for the assessment of iron stores. Of 8 CRF patients who had not been given intravenous iron, oral iron or blood transfusion, 2 had greater iron stores than the control group. Acta haemat. 64: 265-270 (1980) Bone Marrow Cellularity and Iron Stores in Chronic Renal Failure Darrel O. Ho-Yen, Najma Saleem, Laura W...

...S. Vatanavicharn; M. Anuwatanakulchai; M. Tuntawiroon; R. Suwanik; P. Wasi Intestinal 59 Fe absorption was measured in 16 patients with β -thalassaemia/haemoglobin E disease and in 5 normal controls, using a total-body counting technique. The average iron absorption in the patients was 62...

...S. Fargion; M.T. Taddei; M.D. Cappellini; A. Piperno; G. Fiorelli Serum iron, transferrin saturation, serum ferritin and urinary iron excretion have been tested in a group of Italian subjects with beta-thalassemia trait. A number of these subjects, mostly men, had signs of increased iron load...

...A.F. Zamorano; F. Arnalich; Sánchez Casas; A. Sicilia; C. Solis; J.J. Vázquez; R. Gasalla One hundred pregnant women, not anemic and not receiving iron or vitamin supplements, were chosen at random among the three trimesters of pregnancy to determine the incidence of unexpected iron, plasma folate...

...F. Madanat; M. El-Khateeb; M. Tarawaneh; S. Hijazi The value of serum ferritin in assessing iron status was studied in 192 preschool age children between the ages of 3 and 60 months. Children were considered to have iron deficiency if the transferrin saturation was less than 16% and the peripheral...

...Catherine Rice-Evans; Erol Baysal Even though the development of the membrane abnormalities in sickle cell erythrocytes is due to the presence of a mutant gene product, sickle cell anaemia is in a sense a membrane disease. In particular, the presence of iron-containing breakdown products...