..., instructions or products referred to in the content or advertisements. Interferon Multiple myeloma Thalidomide Autologous hematopoietic stem cell transplant Bisphosphonates In the United States, cancer is a major public health problem and the second most common cause of death, with 1 in 4...

... on the role of immunotherapy, including monoclonal antibodies, radio-labeled monoclonal antibodies and interferon-α in the treatment of patients with follicular lymphoma. We aimed to summarize the data from systematic reviews assessing immunotherapy for these patients. A search through Medline...

...J.V. Malfuson; T. Fagot; J. Konopacki; B. Souleau; S. Cremades; T. de Revel Hairy cell leukemia (HCL) is a rare, chronic, B-cell, lymphoproliferative disorder. Treatment has been revolutionized by the advent of interferon (IFN)-α and purine analogs (PA). First-line therapy with PA yields complete...

.... Interferon Leukopoiesis Lymphatic reaction Tilorone Acta haemat. 47: 49-58 (1972) Effect of Tilorone HCI, an Oral Interferon-Inducer, on Leukopoiesis in Rats G. Z binden and E. E mch Department of Experimental and Toxicological Pathology, Institute of Pathological Anatomy, University of Zurich, Zurich...

...Kimberley McGinnes; Ronald Penny The aim of this study was to determine the effects of interferon on in vitro immunoglobulin synthesis by the plasma cells of patients with multiple myeloma. Bone marrow cultures were set up in the presence of media alone or α-interferon. Supernatants were harvested...

...David Claxton; Hagop Kantarjian; Razelle Kurzrock; Jose M. Trujillo; Jordan U. Gutterman; Moshe Talpaz A patient whose chronic myelogenous leukemia (CML) was treated with interferon alpha (IFN-α) is described. The disease showed karyotypic evolution during the chronic phase and the later myeloid...

...C.K. Arthur; D.D.F. Ma Thirty patients with chronic myeloid leukemia in chronic phase and less than 1 year from diagnosis were treated with a combination of interferon alfa-2a (IFN) 9 million units daily continuously and intermittent low-dose cytosine arabinoside (Ara-C) 20 mg/m 2 daily for 21 days...

...Antonio Palumbo; Mario Boccadoro; Lucia A. Garino; Gabriele Gallone; Roberto Frieri; Alessandro Pileri Interferon-α-2b (IFN) has been demonstrated to prolong remission duration and survival in responding multiple myeloma (MM) patients. The aim of this study was to intensify maintenance therapy...

...Daniele Vallisa; Luigi Cavanna; Raffaella Berté; Francesco Merli; Francesco Ghisoni; Luigi Buscarini The widespread use of alpha-interferon (IFN-α) therapy in different diseases draws attention to its side effects, such as autoimmune-related diseases, especially thyroid autoimmune dysfunctions...

...Fumiyasu Nakamura; Akira Andoh; Hitoshi Minamiguchi; Keiko Hodohara; Yoshihide Fujiyama; Tadao Bamba A 55-year-old man with myelofibrosis was treated with natural α-interferon with a good hematologic response. Initially, he had anemia, leukocytosis, thrombocytosis and hepatosplenomegaly. A bone...

... Stenke; Jesper Stentoft; Ingemar Turesson; Ann-Marie Udén; Anders Wahlin; Lars Vilén; Ole Weis-Bjerrum In the present study we combined interferon (IFN) and hydroxyurea (HU) treatment, intensive chemotherapy and autologous stem cell transplantation (SCT) in newly diagnosed chronic myelogenous leukemia...

...Li-Gen Liu; Hideo Tanaka; Kinro Ito; Takuo Ito; Tanvira A. Sultana; Taiichi Kyo; Akiro Kimura Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an interferon (IFN)-induced molecule with apoptotic activity. We examined gene mutations in the death domains of TRAIL receptor 1 (TRAIL...

...Pia Raanani; Isaac Ben-Bassat Interferon (IFN), a leukocyte-derived cytokine, has been used to treat several hematological malignancies. The most common adverse effects of IFN are flu-like symptoms. Autoimmune side effects are infrequent but may be hazardous and irreversible. These may occur...

...Rita Rachmani; Abraham Avigdor; Mona Youkla; Pia Raanani; Moshe Zilber; Mordchai Ravid; Isaac Ben-Bassat Two patients with chronic myelogenous leukemia are described in whom thrombotic thrombocytopenic purpura (TTP) developed following treatment by interferon-α. In one of the patients...

...Aliza Zeidman; Dror Dicker; Moshe Mittelman The role of interferon (IFN) in the treatment of chronic myeloid leukaemia (CML) has been established. Many adverse effects have been reported, but vasospasm has been extremely rare. We report 2 CML patients who developed such complications. A 56-year-old...

... these markers in 19 interferon (IFN)-treated patients before and after a 6-month course of IFN-α. The serum concentrations of IV-C and HA were correlated with the stage of fibrosis (IV-C r = 0.38; HA r = 0.78). These markers fell only in complete responders showing sustained clearance of serum HCV RNA by IFN...