... show clinical heterogeneity ranging from nearly asymptomatic to transfusion-dependent thalassemia. The underlying disease modifying factors remain largely obscure. Methods: To elucidate the correlation between ineffective erythropoiesis and β 0 -thalassemia/hemoglobin E (HbE) disease severity, in vitro...

... labelling’ of bile pigment, following administration of labelled haemoglobin precursors, could be due to the breakdown of the contents of the extruded nucleus during the normal process of red cell maturation, rather than to the existence of ineffective erythropoiesis in which the entire cell is destroyed...

... Autoradiography Cytophotometry DNA synthesis Erythroleukaemia Ineffective erythropoiesis ‘Megaloblastoid’ erythroblasts Acta haemat. 53: 65-74 (1975) Some Aspects of Erythropoietic Cell Proliferation in Erythroleukaemia P. S. M itrou, M. F ischer and K. H übner1 Abteilung für Hämatologie (Leiter: Prof. Dr...

... to in the content or advertisements. Autoradiography Cytophotometry DNA synthesis Ineffective erythropoiesis Megaloblastoid erythroblasts Preleukaemia Acta haemat. 54: 271-279 (1975) Proliferation of Ineffective Erythropoiesis with Nuclear Abnormalities and Megaloblastoid Appearance in Preleukaemia P...

... erythropoiesis and normal utilisation of plasma iron; stage III with ineffective erythropoiesis. This classification seems to correlate better with the clinical course of the disease than the histological staging and, furthermore, seems to have some prognostic relevance. 3 3 2009 © 1976 S. Karger AG...

..., consisting of a striking accumulation of tetraploid unlabelled cells. Therefore, the technique used may be suitable as a diagnostic tool for evaluation of new types of ineffective erythropoiesis. © 1975 S. Karger AG, Basel 1975 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved...

... erythrocytes do not seem clearly linked by cause-effect relationships, they probably derive from several cooperating factors in pathological erythroid precursors, leading to RBC membrane damage. Dysmyelopoietic syndromes Erythrocyte glycolysis Globin chain synthesis Ineffective erythropoiesis Red cell...