... thrombopoietin (rhTPO), and hetrombopag for adult immune thrombocytopenia (ITP). Methods: Randomized controlled trials (RCTs) of the five therapies from inception to June 1, 2022, were included. The efficacy outcome was the rate of platelet response, defined as the achievement of platelet counts above 50 × 10 9...

...Mingling Sun; Xiujuan Wang; Lei Wang; Xinyou Wang; Wenxia Fan; Ying Liu; Qinzhi Li; Ning Zhang; Xinhong Guo Introduction: Immune thrombocytopenia (ITP) is an autoimmune disease characterized by thrombocytopenia. Herein, we sought to identify potential immune-related therapeutic targets in ITP...

.... 2022 COVID-19 mRNA vaccine Immune thrombocytopenia Safety Surveillance Platelet count Immune thrombocytopenic purpura (ITP) is characterized by a low platelet count (less than 100,000/µL = 100 × 10 9 /L) resulting from platelet destruction and impaired platelet production [ 1...

...Daehun Kwag; Jae-Ho Yoon; Gi June Min; Sung-Soo Park; Silvia Park; Sung-Eun Lee; Byung-Sin Cho; Ki-Seong Eom; Yoo-Jin Kim; Hee-Je Kim; Seok Lee; Chang-Ki Min; Seok-Goo Cho; Dong-Wook Kim; Jong Wook Lee Objectives: Although splenectomy has long been second-line option for immune thrombocytopenia...

...Amit R. Mehta; Aron Kefela; Charina Toste; Donald Sweet Patients with immune thrombocytopenia (ITP) are at increased risk for bleeding and are paradoxically at increased risk for thrombosis. Many patients with ITP have underlying cardiovascular (CV) disease and/or other thrombotic risk factors...

...Midori Ishiyama; Masayuki Shiseki; Kentaro Yoshinaga; Michiko Ryuzaki; Yuki Izuka; Aya Watanabe; Norina Tanaka; Akihito Shinohara; Shotaro Hagiwara; Junji Tanaka To evaluate the long-term efficacy of high-dose dexamethasone (HD-DXM) treatment for immune thrombocytopenia (ITP), we retrospectively...

...Yue He; Dexiang Ji; Wei Lu; Guoan Chen Immune thrombocytopenia (ITP) is an acquired autoimmune disorder characterized by persistent thrombocytopenia resulting from increased platelet destruction and a loss of autoimmune tolerance. The pathogenesis of ITP is highly complex. Although ITP may...

...Nichola Cooper; Quentin A. Hill; John Grainger; John-Paul Westwood; Charlotte Bradbury; Drew Provan; Jecko Thachil; Nicholas Ramscar; Anuja Roy Background: Recent evidence suggests that in patients with immune thrombocytopenia (ITP) with a stable response on thrombopoietin receptor agonists...

... production in bone marrow. Since PA-IgG and IPF are increased in patients with immune thrombocytopenia (ITP), reflecting amounts of platelet antibodies and compensatory platelet production, respectively, we hypothesized that these laboratory findings may provide useful markers for predicting treatment...

... or not the IPF can predict the treatment response to corticosteroids in adult patients with primary immune thrombocytopenia (ITP). Methods: Forty-six patients who had been newly diagnosed with primary treatment-naïve ITP and started treatment with corticosteroids were analyzed. Results: Among the 46 primary ITP...

...Yuen-Chin Ong; Hung Chang; Ta-Sen Yeh; Ming-Chung Kuo; Pei-Ling Li; Po-Nan Wang; Tung-Liang Lin; Jin-Hou Wu; Yu-Shin Hung Introduction: Splenectomy is an important and potentially curative treatment for immune thrombocytopenia (ITP). Laparoscopic splenectomy (LS) has replaced open splenectomy (OS...

...Johannes Matschke; Hannes Müller-Beissenhirtz; Jürgen Novotny; Ilona Vester; Bernd Hertenstein; Lewin Eisele; Hildegard Lax; Claudia Ose; Ulrich Dührsen Oral prednisone is considered the standard first-line therapy of adult immune thrombocytopenia, but its long-term efficacy is limited. We...

... physicians seem reluctant to recommend splenectomy for elderly patients with immune thrombocytopenia (ITP), we investigated the safety and efficacy of splenectomy and the predictive factors for response in these patients. Methods: 184 patients with primary ITP were retrospectively analyzed based on age...

... of primary immune thrombocytopenia (ITP). We conducted a large, single-arm study ( clinicaltrials.gov ; NCT00508820) with broad entry criteria to evaluate the safety of romiplostim in adult ITP. Patients (n = 407) with ITP lasting 0.03-57.14 years and low platelet counts (median 14.0 × 10 9 /l...

...Banhe Din; Xingwen Wang; Yuye Shi; Yufeng Li Background: To tackle the problems associated with high-dose dexamethasone (HD-DXM) in patients with immune thrombocytopenia (ITP). Aim: To compare the efficacy of HD-DXM with or without low-dose dexamethasone maintenance in untreated ITP patients...

... immune thrombocytopenia (ITP) with an insufficient response to corticosteroids, immunoglobulins or splenectomy. In the present case series, we present 4 nonresponding patients with chronic ITP who achieved maintenance of complete response (CR) for a period of at least 6 months on eltrombopag treatment...

...Nana Mizuno; Eriko Kanamori; Hiroko Saito; Naomi Murakami; Naoko Tojo; Shuji Tohda We report a case of gray platelet syndrome (GPS) associated with immune thrombocytopenia (ITP) at presentation. A 22-year-old male patient presenting with petechiae on his limbs was diagnosed with ITP due...

..., this observation is in support of this etiology to be considered in Takayasu’s arteritis. Acta haemat. 64: 338-340 (1980) Anti-Factor IX Circulating Anticoagulant and Immune Thrombocytopenia in a Case of Takayasu s Arteritis A. Torres, J. F. Lucia, A. Oliveros, C. Vazquez and M. Torres Services of Hematology...

...Haruki Kondo; Takashi Oyamada; Akinori Mori; Hajime Sumi; Katsushi Kurosu; Eiji Kajii; Atsuo Mikata A case of direct-antiglobulin-test (DAT)-negative auto-immune haemolytic anaemia (AIHA) and immune thrombocytopenia (ITP) associated with Hodgkin’s disease (HD) is reported. A 52-year-old male...

... 1995;21:613–619. 4. Nagamine T, Ohtuka T, Takehara K, Arai T, Takagi H, Mori M: Thrombocytopenia associated with hepatitis C viral infection. J Hepatol 1995;24:135–140. 5. Marson P, Cordiano A, Lazzaro RA, Silla R, Girolami A, Fabris F: Anti-hepatitis C virus (HCV) in immune thrombocytopenia (ITP...