... of hepcidin synthesis, leading to increased intestinal iron absorption. Objectives: The objectives were to characterize and elucidate a possible association between gene expression profile, hepcidin levels, disease severity, and markers of inflammation in HFE -associated HH patients. Methods: Thirty-nine HFE...

... only a part of the daily need is replaced by duodenal absorption. The principal liver-produced peptide called hepcidin plays a fundamental role in iron metabolism. It directly binds to ferroportin, the sole iron exporter, resulting in the internalization and degradation of ferroportin. However...

...Cadiele Oliana Reichert; Joel da Cunha; Débora Levy; Luciana Morganti Ferreira Maselli; Sérgio Paulo Bydlowski; Celso Spada Iron is an essential metal for cell survival that is regulated by the peptide hormone hepcidin. However, its influence on certain diseases is directly related to iron...

...Eleanor Ryan; John D. Ryan; Jennifer Russell; Barbara Coughlan; Harold Tjalsma; Dorine W. Swinkels; Stephen Stewart; John P. Crowe Background/Aims: Innately low hepcidin levels lead to iron overload in HFE -associated hereditary haemochromatosis. Methods: This study compared hepcidin and non...

...Cristiane S. Weber; Luis Beck-da-Silva; Livia A. Goldraich; Andréia Biolo; Nadine Clausell Background: Anemia is a prevalent condition in heart failure with multiple potential causes. The complex interaction between iron stores, hepcidin, inflammation and anemia is poorly comprehended. We tested...

... regarding the severity of iron overload and/or the age at presentation, are all either due to hepcidin deficiency or to the inability to increase hepcidin levels according to iron stores. The second subgroup of hemochromatosis is caused by autosomal dominant mutations in the SLC40A1 gene encoding the iron...

...) and results in increased morbidity and mortality of the underlying disease. Anemia of chronic disease is mediated by inflammatory cytokines and is characterized by low serum iron (hypoferremia) and often increased reticuloendothelial stores of iron. Hepcidin is the master regulator of iron homeostasis and its...

...Elizabeta Nemeth; Tomas Ganz Hepcidin is the central regulator of systemic iron homeostasis. Dysregulation of hepcidin production results in a variety of iron disorders. Hepcidin deficiency is the cause of iron overload in hereditary hemochromatosis, iron-loading anemias, and hepatitis C. Hepcidin...

...Pauline Lee Iron, an essential element for life, is regulated primarily at the level of uptake, storage, and transport in order to maintain sufficient availability for normal physiology. The key protein in iron homeostasis is a 25-amino-acid peptide, hepcidin, which modulates the amount of iron...

...Theodoros Eleftheriadis; Charalambos Kartsios; Vassilios Liakopoulos; Georgia Antoniadi; Maria Ditsa; Christos Papadopoulos; Georgios Anifandis; Aliki Skirta; Dimitra Markala; Ioannis Stefanidis Introduction: Prohepcidin is the precursor of hepcidin, a liver-derived peptide involved in iron...