... factor IX (rFIX) has been increasingly used in hemophilia B (HB) patients. Monitoring of blood levels of EHL rFIX allows to obtain pharmacokinetic (PK) parameters in order to optimize and personalize therapeutic scheme. We describe a case of a young male with severe HB who successfully underwent aortic...

...Eriko Uchida; Kazutoshi Komori; Takashi Kurata; Masashi Taki; Kazuo Sakashita Treating patients with hemophilia and inhibitors is often problematic. The presence of inhibitors negatively impacts the effectiveness of treatment to achieve hemostasis especially in patients with hemophilia B, owing...

... chromosome (45XO). The parents were cytogenetically normal. The activity of factor IX in the patient was markedly abnormal (less than 1%). It is suggested that XX (ring)XO mosaicism permitted expression of the abnormal X-linked gene. Hemophilia B Karyotype Mosaicism Ring chromosome Turner’s syndrome...

...M. Mares; M.T. Sartori; M. Carretta; A. Bertaggia; A. Girolami A hemophilia B patient, seropositive for HIV antibodies since 1984, came to us in March 1989 with a severe necrotizing lesion of the nose. It was an erythematous lesion and looked like rhinophyma. Microbiological examination of the skin...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Hemophilia B Hemophilic arthropathy Polyarthritis, group B streptococcal...

...R.C.R. Ljung The nature of the mutation in the factor IX gene is an important factor in determining whether a patient with hemophilia B will develop an inhibitor. In a series of 62 Swedish families with hemophilia B, including 30 with the severe form, approximately one third of the families...

....) or tranexamic acid (AMCA; Cyklokapron, Kabi Pharmacia, Pisca-taway, NJ.) was examined for safety and efficacy in patients with hemophilia B. In a retrospective review of 19 patients treated with monoclonal antibody-purified factor IX and EACA on 35 occasions, bleeding was successfully controlled...

... IX concentrate Hemophilia B Immunoaffmity chromatography Mononine Acta Haematol 1995;94(suppl 1):25 34 Fred Feldman Sudhish Chandra Chin Huang Technical Development Department, Armour Pharmaceutical Company, Collegeville, Pa., USA Improved Safety from Plasma Derivatives: Purification and Viral...

... in patients with hemophilia B indicate that high-purity factor IX concentrates contain significantly fewer potentially thrombogenic contaminants than PCCs. A recent in vitro study from our laboratory used highly sensitive assays to analyze the relative purity of these newer products. The following products...

...Morteza Karimipoor; Leila Kokabee; Esmat Kamali; Shohreh Zare Karizi; Sirous Zeinali Hemophilia B, a recessive X-linked coagulopathy, is rare in females, and only a few cases have been reported so far. In this report, we describe a 9-year-old female, offspring of a consanguineous marriage...

...Shrimati Shetty; Kanjaksha Ghosh; Dipika Mohanty Hemophilia B is rare in females and only a few cases have been reported. In this report, we describe a girl with a clinically severe course of hemophilia B but with a normal 46,XX karyotype. She had no signs of Turner’s syndrome or any other...