... (PK parameters) in adult patients with severe hemophilia A (SHA), draw up individualized preventive treatment plans, and observe clinical efficacy. Methods: Forty SHA patients treated in our hospital from January 2018 to May 2019 were enrolled, with their age, weight, blood types, bleeding types...

...Paulette Bryant; Aikaterini Boukouvala; Jenny McDaniel; Danielle Nance Approximately 50% of female carriers of hemophilia A have factor VIII (FVIII) levels below 0.5 IU/dL and may be categorized as having mild hemophilia. Females with hemophilia may go undiagnosed for years because the most common...

.... Three previously treated patients with severe hemophilia A (HA) without inhibitors (baseline FVIII activity <0.01 IU/mL) received 50 IU/kg N8-GP every fourth day or twice weekly over 5 years as part of the pathfinder2 trial. Patient samples were monitored using the Pathromtin® SL aPTT reagent...

...Kirk D. Wyatt; Lea M. Coon; Dawn N. Rusk; Vilmarie Rodriguez; Deepti M. Warad The development of factor VIII inhibitors remains a significant clinical challenge in the management of hemophilia A. We present a patient of mixed ethnicity with severe hemophilia A who was found to have a F8 gene...

...Marc Jacquemin This concise review is focused on genetic, molecular and clinical aspects of von Willebrand disease (VWD) type 2N and of mild hemophilia A due to mutations impairing FVIII-von Willebrand factor (VWF) interactions. Missense mutations in the VWF gene impairing the binding to FVIII do...

... of antihemophilic factor (AHF) activity, a low AHF activity/AHF antigen ratio, normal Ristocetin-induced platelet aggregation and a normal level of von Willebrand factor activity. These findings were consistent with the diagnosis of classic hemophilia A which was confirmed by the results of similar studies in nine...

...A. Girolami; Dal Bo Zanon; F. Fabris; R. Franzoso A patient with combined factor VII and factor VIII deficiency is discussed. The propositus is a 21-year-old male who presented a mild bleeding tendency. The patient appears to be a hemophilia and at the same time heterozygote for factor VII...

...Dal Bo Zanon; M. Vicarioto; A. Girolami; A. De Rossi; A R. Del Mistro; L. Chieco-Bianchi The first fatal case of AIDS in an hemophiliac observed in Italy is reported. The propositus is a 53-year-old hemophilia A patient who died on the 8th December, 1984. AIDS was documented clinically...

...Jayesh Mehta; Seema Singhal; M.V. Kamath; B.C. Mehta A randomized double-blind placebo-controlled crossover trial of danazol was carried out in 19 cases of hemophilia A. Danazol was given for 3 months at a dose of 150 mg/day to patients under 15 years of age, and 300 mg/day to older patients...

...Kate Khair; Kingsley Lawrence; Regina Butler; Eadaoin O’Shea; Beverly A. Christie This paper reports findings from a global survey of practice patterns for severe hemophilia A. Nurses from 105 hemophilia treatment centers in the US, the UK, Canada and Sweden responded to a questionnaire...

... with Severe Hemophilia A: Results of a Prospective, Multicenter, Open-Label Phase III Study" by Nemes, L. et al, which was published online 28 February 2008, has been withdrawn at the authors request. © 2008 S. Karger AG, Basel 2008 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved...

...A. Girolami; E. Ruzzon; F. Fabris; C. Varvarikis; R. Sartori; B. Girolami Myocardial infarction and other arterial occlusions are considered to be rare in hemophilia A. However, a systematic study of the subject has never been attempted. All case reports of myocardial infarction or other arterial...

...Farzaneh Towfighi; Soheila Gharagozlou; Ramazan Ali Sharifian; Anoushirvan Kazemnejad; Khadijeh Esmailzadeh; Mohammad Reza Managhchi; Fazel Shokri Factor VIII (FVIII) inhibitor antibodies are produced against functional epitopes of FVIII in about 30% of severe hemophilia A patients leading...

... a few Alu insert mutations have been described so far. In this paper we present an Alu retroposition event in a family with a severe form of hemophilia A. The inserted Alu element belonging to the youngest Yb8 subfamily disrupts the reading frame at methionine 1224, exon 14 of the factor VIII gene...

...Hale Ören; Işın Yaprak; Gülersu İrken In 58 hemophilia A patients aged 1–18 years (mean 9.5 ± 4.7 years), the prevalence of inhibitors was found to be 27% by the Bethesda method in November 1995. Inhibitor activity was not detected in any of 14 patients with mild hemophilia while it was present...