...Shao-xue Ding; Tong Chen; Ting Wang; Chun-yan Liu; Wen-li Lu; Rong Fu Objectives: This meta-analysis aimed to evaluate the risk of clonal evolution of granulocyte colony-stimulating factor (G-CSF) in acquired aplastic anemia (AA), and whether the use of G-CSF increases the occurrence of secondary...

...Yoichi Takaue; Tetsuya Koyama; Tsutomu Watanabe; Yoshifumi Kawano; Tsuneo Ninomiya; Yasuhiro Kuroda; Akira Hiraoka; Tohru Masaoka The in vivo dose-response potential of recombinant human granulocyte colony-stimulating factor (rG-CSF) in facilitating reconstitution of granulopoiesis was evaluated...

..., daily subcutaneous injection of human recombinant granulocyte colony-stimulating factor (rhG-CSF) at a dosage of 100 μg was started. Neutrophil count increased gradually and reached a plateau of 5,000/ μl by day 25 after administration of rhG-CSF. This observation suggests that rhG-CSF is effective...

... in parallel with the progression of the malignant lymphoma. The supernatant of lymphoma tissue culture contained a high titer of granulocyte colony-stimulating factor (G-CSF), and lymphoma cells were positive when immunohistochemically stained by anti-G-CSF antibody. Western blot analysis and mouse colony...

... administration of granulocyte colony-stimulating factor (G-CSF). To our knowledge, this is the first report which describes in vivo changes of cell surface antigen expression on AML cells after the administration of G-CSF. 19 07 1993 31 12 1993 18 2 2009 Acute myeloid leukaemia Cell...

...Hideo Goto; Chihiro Shimazaki; Toshiyuki Hirata; Eishi Ashihara; Katsunori Ohkawa; Naritoshi Oku; Tohru Inaba; Naohisa Fujita; Masao Nakagawa Because recombinant human granulocyte colony-stimulating factor (G-CSF) has been reported to increase the sensitivity of acute myelogenous leukemia (AML...

...Eishi Ashihara; Chihiro Shimazaki; Toshiyuki Hirata; Katsunori Okawa; Naritoshi Oku; Hideo Goto; Tohru Inaba; Naohisa Fujita; Masao Nakagawa We investigated the effects of long-term therapy with recombinant human granulocyte colony-stimulating factor (rhG-CSF) in a 69-year-old man with severe...

...Nozomi Niitsu; Masanori Umeda Twenty-eight patients (14 with relapsing and 14 with refractory non-Hodg-kin’s lymphoma; NHL) were treated with a combination of CACE chemotherapy (cytosine arabinoside, carboplatin, and etoposide) and recombinant granulocyte colony-stimulating factor (G-CSF...

... remission induction (RI) therapy can also improve the treatment results for AML. Therefore, the current trial attempted to evaluate the efficacy and toxicity of granulocyte colony-stimulating factor (G-CSF) priming and a dose intensification of Ara-C in RI chemotherapy for AML. Methods: A total of 29...

...Ninette Amariglio; Jasmine Jacob-Hirsch; Avichai Shimoni; Merav Leiba; Gideon Rechavi; Arnon Nagler Granulocyte colony-stimulating factor (G-CSF) is widely used for the mobilization of hematopoietic stem cells from normal donors. The mechanism of induced mobilization has recently been elucidated...

... granulocyte colony-stimulating factor therapy because of severe neutropenia. Hepatosplenomegaly was not observed during her follow-up. Extramedullary hematopoiesis disappeared after growth factor therapy was stopped. Although the neutropenia was alleviated by growth factor administration, the appearance...

... for advanced-stage chronic myelogenous leukaemia (CML). Therefore, we evaluated in vitro the combined effect of imatinib and granulocyte colony-stimulating factor (G-CSF) on proliferation and apoptosis of Bcr-Abl-expressing leukaemic cells to infer the safety of G-CSF administration. In KU812 and K562 cell...

... human granulocyte colony-stimulating factor (G-CSF) on myelopoiesis of human BM, since the addition of TPO to G-CSF gave rise to significantly more granulocyte-macrophage colonies (p = 0.0001). Besides its well-known significant role in megakaryopoiesis, TPO also has synergistic effects...

...Haruki Kondo; Yasunori Kasahara; Akinori Mori We report a patient with myelodysplastic syndrome (MDS), refractory anaemia with excess blasts in transformation, in whom complete remission (CR) was achieved with the administration of granulocyte colony-stimulating factor (G-CSF). The 76-year-old...

... cytokines. The granulocyte colony-stimulating factor (G-CSF) level was significantly elevated in MDS patients, and the serum G-CSF concentration clearly correlated with the percentage of LAP-positive cells. Thus, the LAP activity in RA is higher than in normal subjects, and G-CSF is thought to be one...

...Shion Imoto; Makoto Hashimoto; Mitsuko Miyamoto; Tohru Murayama; Mika Murayama; Masanori Nakamura; Toshimitsu Matsui; Kazuo Chihara; Ryukichi Ryo Clinical value of granulocyte colony-stimulating factor (G-CSF) for autoimmune neutropenia (AIN) has not been well established. We experienced an adult...

...Akimichi Ohsaka; Katsu Saionji We examined the in vivo effect of granulocyte colony-stimulating factor (G-CSF) on the surface expression of putative counterligands for endothelial selectins on neutrophils in healthy volunteers. G-CSF (50 µg/m 2 /day) was administered subcutaneously to 5 healthy...

...Yasushi Takamatsu; Toshihiro Miyamoto; Hiromi Iwasaki; Shigeyoshi Makino; Kazuo Tamura A patient with hypoplastic acute myelogenous leukemia (AML) who achieved remission with granulocyte colony-stimulating factor (G-CSF) alone is reported. The 59-year-old male patient received antibiotics and G-CSF...