... of neutrophils were similar ( p = 0.199), although higher for platelets with Bu ( p = 0.044). Additionally, graft failure was 0% and 20.0% in the Bu and control groups, respectively ( p = 0.004). In both groups, the incidence of grades III–IV (or grades II–IV) acute graft-versus-host disease (GVHD) and chronic...

...Thomas Weber; Andreas Schmidberger; Kinga Ligeti; Marcus Bauer; Andreas Rosenwald; Lutz P. Müller Introduction: Skin rash is a first symptom of acute graft-versus-host disease (GvHD) after allogeneic stem cell transplantation (ASCT) but can also be caused by viruses. The relevance of virus DNA...

...Feiyan Wang; Lan Luo; Zhenyang Gu; Nan Yang; Li Wang; Chunji Gao Background: Chronic graft-versus-host disease (cGVHD) remains a major cause of late non-recurrence mortality despite remarkable improvements in the field of allogeneic hematopoietic stem cell transplantation. Although recent studies...

... manifestations of graft-versus-host disease (GVHD). Anti-glutamic acid decarboxylase (GAD) antibody-associated cerebellar ataxia is a well-established disorder of autoimmune origin, but there are no reports in the literature of its occurrence following allo-HCT. We describe a middle-aged woman with chronic GVHD...

...Laila Schneidewind; Thomas Neumann; Florian Knoll; Kathrin Zimmermann; Sigrun Smola; Christian Andreas Schmidt; William Krüger Background: The association of polyomaviruses BK and JC with other opportunistic infections and graft-versus-host disease (GvHD) in allogeneic stem cell transplantation...

..., p < 0.001), acute graft-versus-host disease (GVHD) ≥grade 2 (HR 1.908, p = 0.048) and chronic GVHD (HR 0.364, p = 0.001) affected overall survival (OS). The initial cytogenetic risk groups were not a significant risk factor for OS in allogeneic settings. The 2-year OS rate was 44.0 ± 15.9...

...Zhixin Sheng; Huanwen Ma; Wenzheng Pang; Shanona Niu; Jingbo Xu To assess the effect of prophylactic treatment with antithymocyte globulin (ATG) on graft-versus-host disease (GvHD) in myeloablative transplant patients, we performed a meta-analysis of randomized and cohort studies. Medline, Embase...

...Maria Michael; Avichai Shimoni; Arnon Nagler Chronic graft-versus-host disease (GVHD) is a severe complication of allogeneic stem cell transplantation, with a substantial impact on the quality of life and survival, still lacking with regard to an optimal therapeutic strategy. Corticosteroids...

..., instructions or products referred to in the content or advertisements. Placenta Mesenchymal stem cells Stem cell transplantation Graft-versus-host disease To investigate the immunoregulatory effect of human PD-MSCs using mixed allogeneic lymphocytes in vitro, we cultured MMC-inactivated PBMNCs...

... (rs2280789), were genotyped, and the effects of the genotypes and haplotypes of RANTES on clinical outcomes were analyzed. The competing risk regression analysis was used to investigate the relationship between the polymorphisms and the cumulative risk of graft-versus-host disease (GVHD). An AGC haplotype...

... compared the results of allogeneic peripheral blood stem cell transplantation (PBSCT) from unrelated and related donors in 142 consecutive patients with acute myeloid leukemia (AML). The cumulative incidence of acute graft-versus-host disease (GVHD) was 37.6% in the related PBSCT group and 53.7...

... paired immunoglobulin-like B gene (PIR-B) DCs and the effect of PIR-B-DCs on graft-versus-host disease (GVHD) was analyzed after allogeneic bone marrow (BM) transplantation (BMT). Therefore, 1 × 10 6 recipient-derived PIR-B-DCs were injected into BALB/c (H-2k d ) mice using BM-splenocyte grafts from...

...Alois A. Gratwohl; Malcolm I. Bull; Robert G. Graw, jr.; Larry Norton; Turid Knutsen Methotrexate (MTX) followed by citrovorum factor (CVF) rescue was evaluated for its effectiveness in reducing graft-versus-host disease (GVHD) in lethally irradiated dogs transplanted with bone marrow from...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Acute leukemia Bone marrow transplantation Graft-versus-host disease Terminal...

... by the IBMTR report. The treatment of the spleen (splenectomy, radiation, none) was found not to influence the outcome by the EBMT, but the same group is conducting a second, more extensive randomized study. Depletion of postthymic T lymphocytes is an efficient procedure to reduce graft-versus-host disease...

... ciclosporin A (CS-A) as prophylaxis of graft-versus-host disease (GVHD). CS-A trough levels were determined in whole blood by radioimmunoassay (RIA); results were not used to adjust the CS-A dosage. Neither the dose of CS-A administered nor the CS-A concentration and fluctuation of blood levels during...

...Linda J. Burns; Mark W. Westberg; Patrick Burns; Lynell W. Klassen; Nancy E. Goeken; Thomas L. Ray; Donald E. Macfarlane 2 fatal cases of graft-versus-host disease (GvHD) occurred following blood product transfusions given to patients receiving standard chemotherapy for Hodgkin’s disease. GvHD...

... expression, IL-2 production and T-cell proliferation. Adhesion Costimulation Homing Graft-versus-host disease © 1997 S. Karger AG, Basel 1997 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced...

...Richard Champlin; Sergio Giralt; James Gajewski Allogeneic bone marrow transplantation is most commonly used as treatment for leukemia. Allotransplantation is associated with several interrelated immunologic processes, graft rejection, graft-versus-host disease (GvHD) and graft versus leukemia (GvL...

...-versus-host disease, which required the administration of potent immunosuppressants for a long period of time, interfered with the resolution of the IPA. Graft-versus-host disease Invasive pulmonary aspergillosis Severe aplastic anemia Stem cell transplantation Subclavian artery occlusion...