...Benedetta Luppis; Valerto Ventruto Globin chain synthesis has been investigated for the first time in 2 patients homozygous for haemoglobin Lepore, although the 2 brothers have the same haemoglobin genotype the severity of the diseases is very different. The purpose of this study was to try...

... studies and globin chain synthesis analysis (23 subjects). The α/ β ratio of 0.70 + 0.10 was the same as in obligate α -thalassemia -1 ( α -thal) carriers. Hb H inclusion bodies studies were found to be a reliable test for α -thal trait identification, resulting positive in approximately 70% of suspected...

... -Thalassemia Erythroid cell culture Globin chain synthesis Hb E Acta haemat. 64: 42-52 (1980) Beta°-Thalasseraia/Hb E Association Hemoglobin Synthesis in Blood Reticulocytes and Bone Marrow Cells Fractionated by Density Gradient and in Blood Erythroid Colonies in Culture U. Testa, A. Dubart, N. Hinard, F...

... Bart’s ranged from 0.1 to 10% of the total hemoglobin. There was a significant correlation between the Hb Bart’s levels and the decrease in MCV. The relative rates of globin chain synthesis measured by 3H-leucine incorporation was estimated in 15 cord bloods. It was found imbalanced in the 5 cord bloods...

... erythrocytes do not seem clearly linked by cause-effect relationships, they probably derive from several cooperating factors in pathological erythroid precursors, leading to RBC membrane damage. Dysmyelopoietic syndromes Erythrocyte glycolysis Globin chain synthesis Ineffective erythropoiesis Red cell...

... and Biophysics, Istanbul Medical School, and Tiibitak Unit Hemolytic Anemias and Chemical Hematotoxic Disorders , Istanbul, Turkey Key Words. Thalassemia intermedia Globin chain synthesis Low HbF in thalassemia Normal A2 b-thalassemia Abstract. Four homozygotes for thalassemia with normal hemoglobins A2...