...D.G. Wells; V. Marks Erythrocyte transketolase activity is raised in megaloblastic anaemia due to vitamin B 12 deficiency and inversely related to haemoglobin concentration. It si usually normal in cases of megaloblastic anaemia due to folate deficiency though sufficient exceptions occur...

...SN. Wickramasinghe; B. Moffatt The in vitro 3 H-TdR labelling index of eosinophil myelocytes in normal human bone marrow was 16.1%. A similar value was observed in with eosinophilia. Considerably higher – belling indices were seen in the eosinophil myelo- cytes of 1 folate deficient and 2 vitamin B...

... with vitamin B 12 or folate deficiency, in 2 of 8 patients with megaloblastic changes induced by antipurines and in 2 of 8 patients with a macrocytosis caused by alcoholism. The low rate of uptake of 3 H-TdR in the latter 4 cases could not be attributed to an interference with vitamin B 12 or folate metabolism...

...Lars Elsborg Folate deficiency in four patients could be ascribed to anticonvulsant therapy with phenytoin. Their intestinal absorption of folic acid was depressed only when phenytoin was given simultaneously. Otherwise the absorption of folic acid was normal. This malabsorption of folic acid...

...S.N. Wickramasinghe; Valerie Bush Bone marrow fragments from 10 patients with a megaloblastic anaemia due to vitamin B 12 or folate deficiency were studied by electron microscopy and electron microscope autoradiography. A proportion of the erythroblasts showed ultrastructural abnormalities. Some...

...Lars Elsborg In normal subjects, the folic acid absorption (TRIFA test) was independent of age and sex. Among 53 geriatric patients with nutritional folate deficiency, impaired absorption of folic acid was present in 19 (36%). After treatment with folic acid for 4 weeks, the absorption returned...

... to vitamin B 12 or folate deficiency. Although earlier studies employing 0.01 μM 3 H-thymidine had indicated that the incorporation of 3 H-thymidine was subnormal in some patients with vitamin B 12 or folate deficiency, this finding was not seen with higher concentrations of thymidine. In fact, the rates...