... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Multiple myeloma Fluorescence in situ hybridization MYC gene-related abnormalities Additional chromosome 8 MYC gain Chromosomal...

... of patients with leptomeningeal myelomatosis (LMM). Methods: Between April 2005 and April 2016, we identified 16 cases with LMM. The involvement was diagnosed by magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) cytology as well as flow cytometry. Fluorescence in situ hybridization (FISH) was used...

... translocations, namely der(12)t(3;12)(q13;p13), t(11;13;22)(q13;q14;q12) and der(17)t(13;17)(q21;p13), identified by conventional cytogenetics (CC) in 4 MDS patients, were further characterized using a panel of commercial and homemade fluorescence in situ hybridization (FISH) probes. The goal of this study...

..., for the first time, we investigated the putative impact of UGT1A1*28 on CLL incidence and on the formation of the most common chromosomal abnormalities of CLL. UGT1A1*28 was investigated in 109 CLL patients and 108 healthy controls, and was associated with karyotypic and fluorescence in situ hybridization (FISH...

... leukemia (AML) has been made during the last 30 years. The aim of the present study was to assess whether the detection of recurrent gene rearrangements by fluorescent in situ hybridization (FISH) studies and NPM1 and FLT3 gene mutations by molecular studies added clinically relevant information...

... Fluorescence in situ hybridization Translocation t(2;8)(p12;q24), like t(8;22)(q24;q11), is considered as a variant of t(8;14)(q24;q32), both of which represent highly specific rearrangements of Burkitt’s lymphoma/leukemia [ 1, 2 ] and have been rarely found in the indolent type of B cell lymphoma...

... in Interphase and Metaphase Cell Populations: A Combined Chromosome and Primed in situ Labeling Study Key Words Cytogenetics Chromosome aberrations Monosomy 7 Myelodysplastic syndromes Acute myeloid leukemia Fluorescence in situ hybridization Primed in situ labeling Clonal size Abstract Loss of a chromosome 7...

... cytogenetic investigations were carried out on bone marrow. After a standard Ph translocation seen at diagnosis, from the 8th month of therapy all metaphases showed a normal diploid karyotype. Fluorescence in situ hybridization detected residual BCR/ABL-positive inter-phase cells during the 12th month...

...J. Thiele; E. Varus; H.M. Kvasnicka; C. Wickenhauser Repeatedly performed bone marrow biopsies were studied in 30 patients with chronic idiopathic myelofibrosis (CIMF) by fluorescence in situ hybridization to detect and quantify trisomy 8 anomaly during the evolution of disease...

... myeloid leukemia Fluorescence in situ hybridization Imatinib Minimal residual disease Molecular cytogenetics Quantitative RT-PCR Nonquantitative polymerase chain reaction (PCR) methods have been developed to detect various types of BCR-ABL transcripts, which arise as the consequence...

...Luba Trakhtenbrot; Gideon Rechavi; Ninette Amariglio Combined simultaneous analysis of morphology, immunophenotyping and fluorescence in situ hybridization on the same cell offers advantages that may help to disclose the relevance of minimal residual disease (MRD) detection. Morphological analysis...

..., reciprocal translocation between the long arms of chromosomes 9 and 22, t(9;22)(q34;q11). This reciprocal translocation leads to the formation of the bcr/abl fusion gene, the presence of which was confirmed using the highly sensitive fluorescence in situ hybridization technique. The renal biopsy...

...,+der(?)t(?;1)(?;q?1), and no Philadelphia chromosome. Reverse transcription-polymerase chain reaction did not show either major or minor BCR-ABL chimeric mRNA. Spectral karyotyping (SKY) and fluorescence in situ hybridization (FISH) refined the karyotype to 46,X,der(Y)t(Y;1)(q11.1 or .2;q12). The der(Y...

...+). The CML origin of the blasts was confirmed by the detection of the bcr-abl gene rearrangement in the blasts by two-color fluorescence in situ hybridization (FISH). We conclude that fine needle aspiration in combination with immunophenotyping and FISH analysis of the aspirate is a minimally invasive...