...Jingbo Yu; Dilan Paranagama; Becky Hanna; Jackson Tang; Aleksander Chojecki Introduction: This analysis reports demographic and clinical characteristics of patients with physician-diagnosed essential thrombocythemia (ET) receiving cytoreductive therapy in US community clinical practice. Methods...

... groups. In essential thrombocythemia patients, hemoglobin levels and leukocyte counts were significantly higher in JAK2 -positive than in CALR -positive patients (p = 0.023 and p = 0.017, respectively), but the CALR -positive patients had significantly higher platelet counts (p = 0.022). Patients...

... in the P2Y 12 pathway, no previous studies have specifically evaluated P2Y 12 function in MPN or the relationship between P2Y 12 function and the JAK2 V617F mutation. Methods: Forty-one MPN patients were enrolled, including 24 with essential thrombocythemia (ET), 16 with polycythemia vera (PV) and 1...

... by quantitative RT-PCR in polycythemia vera, essential thrombocythemia, early primary myelofibrosis (PMF) and normal hematopoiesis. Our goal was to establish certain miRNAs as potential markers for CMPDs to facilitate the differentiation between these diseases and to further investigate molecular differences...

...Naoki Mori; Kyoichi Totsuka; Noriko Ishimori; Kentaro Yoshinaga; Masanao Teramura; Sanshiro Noguchi; Hideaki Oda; Toshiko Motoji A 69-year-old woman with essential thrombocythemia (ET) developed giant ecchymosis, and she was admitted to hospital. Marked anemia (Hb 8.1 g/dl) accompanied...

.... Essential thrombocythemia Polycythemia vera JAK2 mutation Unusual splanchnic or cerebral vein thrombosis Heparin-induced thrombocytopenia Over the last 10 years, we selected 29 patients with Ph-MPD (9 males and 20 females; 9 with polycythemia vera, PV, and 20 with essential thrombocythemia, ET...

... and lymphoproliferative diseases in the same patient is a rare phenomenon. Methods: We report a case of a patient having essential thrombocythemia (ET) and B-chronic lymphocytic leukemia (B-CLL). In this patient and in 2 relatives with lymphoproliferative disorders, we searched for JAK2 V617F mutation in lymphocytes...

...Alessandro Allegra; Andrea Alonci; Giuseppa Penna; Arianna D’Angelo; Patricia Rizzotti; Angela Granata; Caterina Musolino Background: Splanchnic vein thrombosis (SVT) is a severe complication of essential thrombocythemia (ET). No clear explanation has been given for the occurrence of thrombosis...

...F. Leoni; A. Grossi; P. Rossi Ferrini 14 patients with essential thrombocythemia (ET) and 1 patient with agnogenic myeloid metaplasia received (1-(2-chloroethyl)-cyclohexyl-nitrosourea (CCNU), 80 mg/m 2 , p.o., in a single dose once a month up to three times. Remission was achieved in 13 patients...

... megakaryocyte precursors were identified in 5 patients with essential thrombocythemia (ET) and the 2 patients with acute myelogeneous leukaemia (AML) after recovery from therapeutic aplasia. Small megakaryocyte precursors were rare in controls (C), patients with reactive thrombocytosis (RT) and immune...

...Nashat Y. Gabrail; Thomas W. Martin A patient with chronic lymphocytic leukemia (CLL) and essential thrombocythemia is described. The two disorders were diagnosed synchronously. This association was not treatment related. Review of the literature revealed an additional 9 case reports of CLL...

...Masahiro Murakawa; Takashi Okamura; Kumi Tsutsumi; Satoru Tanoguchi; Takumi Kamura; Tsunefumi Shibuya; Mine Harada; Yoshiyuki Niho Acquired von Willebrand’s disease in a 40-year-old woman affected with essential thrombocythemia (ET) is reported. The profile of plasma von Willebrand factor (vWF...

...Satoshi Hashino; Masahiro Imamura; Sumiko Kobayashi; Yasuyuki Kunieda; Hajime Kobayashi We describe a case of Philadelphia-negative essential thrombocythemia in whom bcr-abl hybrid messenger RNA was detected. The patient suffered from frequent splenic infarctions and myelofibrosis. Interestingly...

...Keisuke Shibata; Yoshinori Shimamoto; Kenji Suga; Masayuki Sano; Miwako Matsuzaki; Masaya Yamaguchi Essential thrombocythemia (ET), one of the chronic myeloproliferative disorders, is a clonal disorder of multipotent stem cells. Although most patients with ET have a prolonged benign course...

...Junya Kuroda; Yosuke Matsumoto; Ruriko Tanaka; Kayoko Kurita; Tsutomu Kobayashi; Daisuke Shimizu; Shinya Kimura; Eishi Ashihara; Shigeo Horiike; Chihiro Shimazaki; Masafumi Taniwaki Overlapping of essential thrombocythemia (ET) and multiple myeloma (MM) has been extremely rare. Our report concerns...

...K. Panteli; N. Zagorianakou; N.J. Agnantis; K.L. Bourantas; M. Bai The aim of this study was to investigate the prognostic relevance of angiogenesis expressed as bone marrow microvessel density (MVD) in 40 patients with essential thrombocythemia (ET). Bone marrow MVD was visualized in paraffin...

...Jürgen Thiele; Hans Michael Kvasnicka; Volker Diehl Patients have previously been described who showed clinical signs and symptoms suggesting essential thrombocythemia (ET), but later transformed to polycythemia vera (PV). From a series of 344 patients with a sustained borderline to moderate...

...David P. Steensma; Ayalew Tefferi Essential thrombocythemia (ET) is a chronic myeloid disorder that is characterized by thrombocytosis, thrombohemorrhagic and vasomotor symptoms, a long median survival, and a low risk of transformation to leukemia. ET can be difficult to distinguish from secondary...

...Carmen Burgaleta; Nuria González; Jesús César Functional studies of granulocytes in polycythemia vera (PV) and essential thrombocythemia (ET) are contradictory. In order to study the possible link between adhesion molecules and functional activity of polymorphonuclear leukocytes (PMNs...

...B. Vantroyen; D. Vanstraelen It is advisable to treat essential thrombocythemia (ET) during pregnancy, because elevated platelet counts can lead to maternal and fetal complications. In order to establish which therapy is more favorable, we undertook a review of the literature. In addition to our...