...Kyung Chul Moon; Jeong-An Gim; Dae Sik Kim; Chul Won Choi; Jung Yoon; Soo-Young Yoon Differentiating the aetiology of thrombocytosis is limited yet crucial in patients with essential thrombocythaemia (ET). MicroRNAs (miRNAs) regulate haematopoiesis and lineage commitment; aberrant expression...

.... Essential thrombocythaemia Chronic myeloid leukaemia JAK2 V617F BCR-ABL1 Myeloproliferative disorders (MPDs) are chronic haematological malignancies characterised by the clonal expansion of a transformed haematopoietic stem cell. Detection of a balanced translocation involving the long arms...

...Achille Pich; Ludovica Riera; Paola Francia di Celle; Eloise Beggiato; Giulia Benevolo; Laura Godio Introduction: Mutations in the JAK2 , CALR , and MPL genes have been shown to have prognostic value in essential thrombocythaemia (ET), but no clear association with morphological changes has been...

...F. Waweru; S.M. Lewis Essential thrombocythaemia was diagnosed in a series of 18 patients on the basis of platelet counts greater than 1,000 × 10 9 /1. Radionuclide studies have been carried out to distinguish thrombocythaemia as a primary disease from polycythaemia vera, myelofibrosis and chronic...

...Nicola Lucio Liberato; Giovanni Barosi; Attilia Costa; Paola D’Elia; Piero Boccaccio We report a male patient in whom a diagnosis of essential thrombocythaemia was made at the age of 25. The clinical course was characterised by recurrent thrombotic episodes during the first few years of the disease...

...P.J. Browett; H.E. Heslop; A.B. Mehta; J.D. Norton A 42-year-old woman presented with clinical and haematological features of essential thrombocythaemia (ET). Cytogenetic investigation revealed a standard t(9;22) Philadelphia translocation in all evaluable metaphases which persisted throughout...

...V. Rametta; F. Ferrara; V. Marottoli; C. Matera; V. Mettivier; R. Cimino We report the disease characteristics and therapeutic results for 25 patient suffering from essential thrombocythaemia (ET), treated with recombinant in terferon-alpha-2b (IFN-α2b). ET was diagnosed according...

...Riitta Jantunen; Eeva Juvonen; Ari Aimolahti; Tapani Ruutu Bone marrow samples of 8 patients with essential thrombocythaemia and three patients with polycythaemia vera were cultured in long-term bone marrow cultures. The production of non-adherent cells and colony-forming unit-granulocyte...

... at the level of the colony-forming unit granulocytes, erythrocytes, macrophages, megakaryocytes. No cytogenetic abnormalities were observed. The criteria which have been proposed to differentiate essential thrombocythaemia from pre-fibrotic thrombocythaemia, as an early phase of idiopathic myelofibrosis...