...Howard S. Oster; Moran Gvili Perelman; Albert Kolomansky; Drorit Neumann; Moshe Mittelman Background: Erythroid stimulating agents (ESAs) have pleiotropic effects, and in animal and human studies those exposed to high erythropoietin had lower blood glucose. Objective: To determine the association...

...Mauricette Michallet; Christoph Losem Chemotherapy-induced anaemia is frequent in cancer patients, with severity depending on the extent of the disease and intensity of treatment. Clinical guidelines recommend erythropoietin therapy to treat or prevent anaemia in some oncology/haematology patients...

..., both of which can cause depression of erythropoietin (EPO) production and bone marrow activity. The cytokines also induce iron deficiency by both reducing gastrointestinal iron absorption and iron release from iron stores located in the macrophages and hepatocytes. Iron deficiency can cause...

... disease Erythropoietin Hepcidin Hypoferremia Inflammation Transferrin The marrow iron is considered the gold standard for the diagnosis of iron deficiency. In subjects with IDA, marrow iron stores are depleted in both erythroid progenitors as well as macrophages. However, in ACD, iron stains...

...) occurs when the obvious causes are excluded while its pathogenesis is still obscure. We investigated its underlying mechanisms in 56 untreated patients with CLL. Methods: Bone marrow (BM) lymphocytic infiltration was estimated in trephine biopsies. Serum erythropoietin (EPO) and tumor necrosis factor-α...

...J.L. Scaro; M.A. Carrera; J.E. Teruel; Raquel Alvarez Prado de Tombolesi Administration of phytohemagglutinin to protein-fasted and polycythemic mice results in a striking increase of spleen response to erythropoietin. An opposite ef- s feet was found in bone marrow. In transplant experiments...

.... Experimental data suggest that starvation decreases the ESF-sensitive stem cell pool. Acta Haemat. 52: 141-150 (1974) Effect of Starvation on the Response to Erythropoietin in the R at1 J. P. N aets and M. W itter 2 Laboratoire de Médecine expérimentale et Laboratoire de Biologie clinique de l Hôpital Brugmann...

...Kodwo-James Raphael Abaidoo The assumption that inability to extract erythropoietin from the kidney is due to a renal lipid inhibitor, which inactivates the hormone during the process of extraction, has been substantiated. Discovery of erythropoietic inhibitory activity in the spleen and liver...

...Tomomitsu Hotta; Hideo Yamada An apparent response to erythropoietin was demonstrated in all marrow cell suspensions from 12 patients with acquired aplastic anemia (8 idiopathic type and 4 drug-induced aplastic anemia). However, the degree of response in aplastic anemia of both idiopathic...

.... These data confirm the hypothesis already formulated regarding the renal origin of the splenic erythropoietic factor and the different nature of the renal erythropoietic factor compared with the plasmatic erythropoietin. Acta haemat. S3: 75-81 (1975) Different Molecular Weight of the Plasmatic Erythropoietin...

... The Johns Hopkins University, International Center for Medical Research, Kathmandu Key Words. Anemia ATP 2,3-Diphosphoglycerate Erythropoietin Hypothy­ roidism Hypoxia Abstract. A comparison of concentrations of 2,3-diphosphoglycerate (2,3-DPG) and adenosine-triphosphate (ATP) in the red cells...

...I.M. Pannacciulli; G.G. Massa; A.G. Saviane; R.L. Ghio; Giovanna L. Bianchi; G.V. Bogliolo The effect of bleeding on spleen colony-forming units (CFU-S) and on in vitro colony-forming cells with colony-stimulating factor (CFU-C) and erythropoietin (CFU-E) has been evaluated. The in vivo...

...Nicolas E. Stathakis; Anthony S. Gidari; Richard D. Levere The responsiveness to erythropoietin of cultured bone marrow cells, obtained from 7 patients with refractory anemia with hyperplastic marrow, was studied. 5 of these patients’ marrows also exhibited sideroblastic changes. Heme synthesis...

...Dov Gorshein; Frank H. Gardner; Warner Tyree; Frank Oski; Maria Delivoria-Papadopoulos Increased plasma erythropoietin (ESF) activity, a rise in RBC 2,3-DPG, and a ‘right shift’ of the oxygen hemoglobin equilibrium curve following androgen administration to mice in ambient or hyperoxic conditions...

... homogenates. The results show that Cleland’s reagent inhibits the activity of the renal and splenic erythro-stimulant factors, whereas it has no effect upon the erythropoietin in anaemic plasma and in plasma-kidney and plasma-spleen incubation mixtures. The activity of erythropoietin, on the other hand...

...F. Krizsa; I. Cserháti After administration of a single 1 IU dose of exogenous erythropoietin to mice or by stimulating endogenous erythropoietin production with androgen, the animals’ thrombocytopoiesis, measured with selenomethionine incorporation, decreased. The suppression of endogenous...

...F. Chiuini; Delia Torre; G. Fanò; A. Viti The effects of an erythropoietin (Ep)-rich plasma fraction and of a commercial preparation of purified Ep (Step I) on the cyclic adenosine monophosphate (cAMP) levels of suspended rabbit bone marrow cells at different incubation times (up to 10 min) were...

...Vittoria Ambrosini; Giovanni B. Principato; Elvio Giovannini; Gigliola Grassi; Piero Toraldo Acid-base balance changes as well as rises in erythropoietin (Ep) levels were studied in rabbits during the first 12 h of either anemic or hypobaric hypoxia and following CoC 2 treatment. Bleeding and CoCl...

...P. Scigalla; V.I. Gudim; V.S. Ivanova; N.A. Fedorov; P. Grossmann The erythropoietin activity and the erythropoiesis inhibiting factor(s) (EIF) were studied in the serum of 10 children and adolescents suffering from terminal renal insufficiency. The influence of haemodialysis on these factors...

...Brian A. Naughton; Philip Liu; Gail K. Naughton; Albert S. Gordon Recently, a factor was discovered in the serum of hepatectomized animals which was capable of augmenting the hepatic erythropoietin response to hypoxia when injected into normal rats. This substance was localized in the liver via...