... cytotoxicity. Collectively, our study demonstrated that TLR4 was essential for the cytotoxicity of CIK cells against tumor cells, which might provide a novel approach to promote the therapeutic efficacy of CIK cells against hematologic malignancy. 13 05 2013 29 07 2013 13 12 2013 © 2013 S...

...G.D. Pegrum; Carol A. Evans; Valerie L. Middleton 14 C-thymidine incorporation and cytotoxicity to a target cell were used to assess response of peripheral blood leucocytes from patients during the course of acute myeloid leukaemia. Studies were made after mixed culture with allogeneic lymphocytes...

...F. Pandolfi; G. Luzi; M.C. Tozzi; F. Aiuti A serum against human lymphoblastic leukemia cells was obtained inoculating rabbits. We studied the specificity of the serum before and after particular absorptions in various clinical conditions. The serum was cytotoxic against many cases of acute...

... of erythroblasts and do not show any cytotoxicity. In addition, a relative increase of granulocytic precursors capable of proliferation was found, suggesting an increase in the resting population of the granulocytopoietic proliferation pool due to extract treatment. However, the extract capable of depressing...

.... The susceptibility to the lysis of the different target cells was HRBC < ORBC < CRBC. An intact neutrophil metabolic burst was essential for the cytotoxic event, since neutrophils from a patient with chronic granulomatous disease failed to kill all three target cells. HRBC and ORBC destruction was prevented...

.... Cytotoxicity Lymphocytes Monoclonal antibodies NK cells Thalassemia Transfusion T subpopulations Acta haemat. 71: 263-269(1984) © S . Karger AG. Basel 0 0 0 1- 5 7 9 2 /8 4 /0 7 14-0263 S 2.75/0 Natural Killer Cell Activity and T Subpopulations in Thalassemia major A. Neri, M. Brugiatelli, P. Iacopino...

...Randall F. Holcombe Peripheral blood mononuclear cells (PBMCs) from patients with Chediak-Higashi syndrome (CHS) exhibit minimal natural-killer-like cytotoxicity by standard 51 Cr-release assays in vitro. However, a CHS-derived γδ-T-cell clone maintained in long-term culture with low-dose...

...Felipe Andrade; Livia A. Casciola-Rosen; Antony Rosen Granzyme B (GrB) is a serine protease that is released by cytotoxic lymphocytes to kill virus-infected and tumor cells. Recent advances in the understanding of GrB have stressed the importance of reassessing the mechanisms by which GrB...

... such as TGF-β, FasL, vascular endothelial growth factor and Muc-1. In the present study, we show that bone marrow cells from a patient suffering from MM IgG/k type, stage IIIA, when cultured, expressed granzyme B and perforin, normally expressed exlusively by cytotoxic T cells (CTLs) and natural killer (NK...