...Russell K. Brynes; Raymond S.M. Wong; Maung M. Thein; Kalpana K. Bakshi; Paul Burgess; Dickens Theodore; Attilio Orazi Background: The long-term effects of eltrombopag on bone marrow (BM) reticulin and/or collagen deposition in previously treated adults with chronic immune thrombocytopenia (ITP...

...Jianlin Qiao; Jane F. Arthur; Margaret Collecutt; Yang Shen; Fi-Tjen Mu; Michael C. Berndt; Amanda K. Davis; Robert K. Andrews; Elizabeth E. Gardiner Introduction: Ligands acting at the platelet collagen receptor, glycoprotein (GP)VI, induce intracellular FcRγ/Syk-dependent signaling pathways...

..., irreversible aggregation in normal subjects. Ten times the usual concentration is required to produce such maximal aggregation. Aggregation in response to collagen is normal as is release of ADP in response to collagen. This anomalous behaviour is not due to a plasma ADPase. This defective behaviour can...

... that allows them to become both the nidus and the stimulus for the precipitation of a meshwork of fibrin. The interactions between platelets and exposed collagen in the damaged vessel wall, plasma and platelet von Willebrand factor, and plasma and platelet fibrinogen can all be considered ‘adhesive...

...Arnon Nagler; Meir Ohana; Merav Leiba; Lilia Levdansky; Raphael Gorodetsky It is a major interest in the field of hematopoietic stem cell transplantation to reduce scarring of healing wounds with overdeposition of collagen due to radiation injury or graft-versus-host disease. Halofuginone (HF...