...Xin Liu; Miao-Miao Cui; Hai-Zhen Zhu; Pei-Yi Fu; Guo-Chuan Wang; Ling Huang Introduction: Chronic myeloid leukaemia (CML) is a myeloproliferative neoplasm characterized by constitutive activity of the tyrosine kinase BCR-ABL1. Drug resistance remains one of the major challenges in CML therapy...

...Jew Win Kuan; Anselm Ting Su; Chooi Fun Leong; Motomi Osato; Goro Sashida The treatment of chronic myeloid leukaemia (CML) requires quantitative polymerase chain reaction (qPCR) to monitor BCR-ABL1 in International Scale (IS). Some normal subjects were found to harbour BCR-ABL1 . We performed...

... Peeters Objectives: To assess interruptions/discontinuations of tyrosine kinase inhibitor (TKI) treatment in Belgian patients with chronic myeloid leukaemia (CML). Methods: This retrospective study included patients with TKI interruptions/discontinuations of ≥4 continuous weeks (no clinical trial context...

...Jiaqi Tan; Mengxing Xue; Jinlan Pan; Jiannong Cen; Xiaomei Qi; Ping Liu; Xiaohong Zhao; Pin Wu; Qinrong Wang; Dandan Liu; Yuejun Liu; Suning Chen; Zhi Wang We retrospectively evaluated the efficacy and safety of dasatinib among 48 Chinese patients with chronic phase chronic myeloid leukaemia...

...Elena Tirrò; Stefania Stella; Michele Massimino; Valentina Zammit; Maria Stella Pennisi; Silvia Rita Vitale; Chiara Romano; Sandra Di Gregorio; Adriana Puma; Francesco Di Raimondo; Fabio Stagno; Livia Manzella BCR-ABL1 -negative myeloproliferative disorders and chronic myeloid leukaemia...

...Miriam A. Wohl; Keith Wood This is the first report of a case of chronic myeloid leukaemia (CML) complicated by myasthenic syndrome. The patient suffered two prolonged periods of idiosyncratic busulphan-induced marrow aplasia, the first occurring 5 months after busulphan was stopped. Between...

...A.N. Bhisey; S.G.A. Rao; S.H. Advani; V. Ray Peripheral blood leucocytes from chronic myeloid leukaemia (CML) patients previously untreated or in relapse are agglutinated by concanavalin A (Con A) at concentrations of 25–400 μ g/ml. Leucocytes from normal subjects, from CML patients in remission...

...A. Pakkala; T. Ruutu; S. Partanen; R. Kovanen; G.H. Borgström; S. Knuutila Chromosome studies were performed on peripheral blood (PB) cells with and without stimulation, and/or on bone marrow (BM) cells from 21 patients with chronic myeloid leukaemia (CML), and 18 patients with myelofibrosis (MF...

... lymphocytic leukaemia Chronic myeloid leukaemia Immunoautoradiography Polycythaemia vera Abstract. Using a quantitative immunoautoradiographic technique with simultaneously exposed internal standards, antigenic sites on A), A)B, Az and A2B erythrocytes were quantitated. The binding of purified...

...L.M. Secker-Walker; H.M. Cooke; P.J. Browett; J.D. Norton; C. Kitchen; A.G. Prentice; H.G. Prentice A 26-year-old man, who presented with bilateral fundal haemorrhages, was found to have chronic myeloid leukaemia (CML). The Ph chromosome was not present but a clone with t(l;9) (p32;q34...

...Luis Bello López; E. Fonseca; F. Manso We report the case of a 52 year-old male in the chronic phase of chronic myeloid leukaemia, with Philadelphia chromosome due to t(9;22) in the karyotype. He was treated with courses of busulfan and hydroxyurea. Fourteen months after initial presentation...

...P.A. McKinney; B.E. Roberts; C. O'Brien; C.C. Bird; I.D.G. Richards; F. Alexander; R.A. Cartwright The results of a case-control study of chronic myeloid leukaemia in adults are reported. 122 cases and 241 controls were interviewed. Excess risks associates with heart disease and related drugs were...

...Miklós Egyed; Balázs Kollár; György Rumi; Éva Keller; János Vass; Sándorné Fekete The cytogenetic responses during the first chronic phase of 11 patients with chronic myeloid leukaemia (CML) treated with all-trans retinoic acid (ATRA) + interferon (IFN) were compared with those of 9 other CML...

...David J. Barnes; Junia V. Melo Chronic myeloid leukaemia (CML) is caused by the product of the BCR-ABL oncogene, located on the Philadelphia (Ph) chromosome. BCR-ABL is generated as a result of a reciprocal t(9;22) chromosomal translocation. The mechanisms responsible for this illegitimate...

...Ivone B. Otazú; María Belén Rivero; Renata Olício; Augusto Pinto; Ilana Zalcberg; Héctor N. Seuánez We have identified a rare BCR-ABL chimaeric gene with multiplex and nested RT-PCR in a patient with an unusually aggressive chronic myeloid leukaemia. cDNA sequencing showed an in-frame rearrangement...

..., this leukaemogenic mechanism has been increasingly recognized in chronic myeloid leukaemias. The fusion gene has often incorporated part of a gene encoding a receptor or cytoplasmic tyrosine kinase, particularly ABL , PDGFRB and FGFR1 . This contrasts with the frequent involvement of genes encoding transcription...

...Jaspal Kaeda; Andrew Chase; John M. Goldman For patients with chronic myeloid leukaemia, methods for monitoring response to treatment have changed considerably in recent years. In the 1980s, the principal approach was repeated examination of bone marrow metaphases for the presence of the Ph...

...Aliza Zeidman; Dror Dicker; Moshe Mittelman The role of interferon (IFN) in the treatment of chronic myeloid leukaemia (CML) has been established. Many adverse effects have been reported, but vasospasm has been extremely rare. We report 2 CML patients who developed such complications. A 56-year-old...