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Keywords: Chronic lymphocytic leukemiaClose
Acta Haematol 1–3.
Published Online: 07 August 2023
...Stefano Molica; Marco Rossi; David Allsup In addition to the European Society for Medical Oncology (ESMO) and National Comprehensive Cancer Network (NCCN) guidelines that are reference standards for the treatment of chronic lymphocytic leukemia (CLL) in Europe and the USA, several consensus...
Acta Haematol 1–15.
Published Online: 27 July 2023
...Ernesto Gargiulo; Rebecca Svanberg Teglgaard; Tereza Faitová; Carsten Utoft Niemann Background: Chronic lymphocytic leukemia (CLL) is a hematological malignancy characterized by immune dysfunction, which significantly contributes to increased morbidity and mortality due to infections. Summary...
Acta Haematol 1.
Published Online: 05 June 2023
...Tamar Tadmor; Guy Melamed; Hillel Alapi; Sivan Gazit; Tal Patalon; Lior Rokach Pregnancies following diagnosis of chronic lymphocytic leukemia (CLL) are rare events, mainly because the disease is typically diagnosed in the elderly. Literature on the topic is based only on case reports, and limited...
Sylwia Popek-Marciniec, Szymon Zmorzyński, Dorota Koczkodaj, Michał Marciniec, Ewa Wąsik-Szczepanek, Agnieszka Karczmarczyk, Małgorzata Michalak-Wojnowska, Agata Filip
Acta Haematol (2023) 146 (4): 277–286.
Published Online: 04 April 2023
... role in the development of chronic lymphocytic leukemia. Nurse-like cells (NLCs) are one of the important elements of the microenvironment of CLL cells. The key role in the interactions of leukemic cells with NLCs is played by chemokines, which may interfere with the programmed cell death process...
Acta Haematol (2022) 145 (1): 54–62.
Published Online: 20 September 2021
...Shenmiao Yang; Rong Zhu; Nan Li; Yu Feng; Rui Zuo; Robert Peter Gale; Xiaojun Huang Introduction: Therapy of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) with drugs such as ibrutinib and rituximab is often associated with immune suppression, opportunistic infections...
Acta Haematol (2021) 144 (5): 508–518.
Published Online: 25 February 2021
... course of SARS-CoV-2. In patients with chronic lymphocytic leukemia (CLL), infections are a main contributor to morbidity and mortality driven by an impaired immune system. Treatment initiation is likely to induce immune modulation that further increases the risk for severe infections. This article aims...
Sanford Kempin, Zhuoxin Sun, Neil E. Kay, Elisabeth M. Paietta, Joseph J. Mazza, Rhett P. Ketterling, Olga Frankfurt, David F. Claxton, Joel N. Saltzman, Gordan Srkalovic, Natalie S. Callander, Gerald Gross, Martin S. Tallman
Acta Haematol (2019) 142 (4): 224–232.
Published Online: 12 November 2019
...Sanford Kempin; Zhuoxin Sun; Neil E. Kay; Elisabeth M. Paietta; Joseph J. Mazza; Rhett P. Ketterling; Olga Frankfurt; David F. Claxton; Joel N. Saltzman; Gordan Srkalovic; Natalie S. Callander; Gerald Gross; Martin S. Tallman Patients with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL...
Acta Haematol (2018) 140 (1): 51–54.
Published Online: 16 August 2018
...Uri Rozovski; Michael J. Keating; Zeev Estrov The immunoglobulin heavy chain gene ( IgHV ) mutation status correlates with the clinical outcome of patients with chronic lymphocytic leukemia (CLL) treated with chemoimmunotherapy. Why the survival rate of patients with unmutated IgHV is worse than...
Acta Haematol (2018) 139 (2): 132–139.
Published Online: 14 February 2018
...Beverly W. Baron; Michael J. Thirman; Mihai C. Giurcanu; Joseph M. Baron We reported that PIM1 kinase is expressed in the lymphocytes of patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). Quercetin, a naturally occurring flavonoid, is a dietary supplement...
Acta Haematol (2015) 134 (4): 208–214.
Published Online: 11 June 2015
... T cell function and stimulates the regulatory T cell population. The objectives were to investigate whether examining PD-1 expression in peripheral T cells of patients with chronic lymphocytic leukemia (CLL) reflected the disease phase and Binet stage and to compare the results with those in healthy...
Maciej Grzywnowicz, Agnieszka Karczmarczyk, Katarzyna Skorka, Malgorzata Zajac, Joanna Zaleska, Sylwia Chocholska, Waldemar Tomczak, Krzysztof Giannopoulos
Acta Haematol (2015) 134 (4): 255–262.
Published Online: 01 April 2015
... activation of these cells. There is growing evidence that chronic lymphocytic leukemia (CLL) cells exploit the PD-1 ligand (PD-L1) to resist antitumor immune reactions and maintain their survival by shaping their own microenvironment. Methods: We used a quantitative RT-PCR method to analyze PD-L1 gene...
Acta Haematol (2014) 132 (2): 240–243.
Published Online: 17 May 2014
...Dimitrios Tzachanis; Ayad Hamdan; Erik J. Uhlmann; Robin M. Joyce This is the case of a 79-year-old man with chronic lymphocytic leukemia who presented with Guillain-Barré syndrome with features overlapping with the Miller Fisher syndrome and Bickerstaff brainstem encephalitis and positive...
Acta Haematol (2014) 132 (2): 237–239.
Published Online: 17 May 2014
... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Autoimmunity Chronic lymphocytic leukemia Alemtuzumab (Campath-1H; Genzyme, Cambridge, Mass., USA) is a chimeric...
Moritz Stuplich, Karin Mayer, Young Kim, Sharmilan Thanendrarajan, Matthias Simon, Niklas Schäfer, Martin Glas, Ingo G.H. Schmidt-Wolf, Ulrich Herrlinger
Acta Haematol (2012) 127 (2): 93–95.
Published Online: 10 December 2011
... rare and has a poor prognosis. We describe the cases of high-grade large B-cell diffuse NHL in a 56-year-old male with chronic lymphocytic leukemia and in a 71-year-old female with previously unknown low-grade NHL, both with initial appearance of neurological symptoms. This report extends...
Mariana Serpa, Israel Bendit, Fernanda Seguro, Flavia Xavier, Marcela Cavalcante, Daniel Steinbaum, Luciana Nardinelli, Vera Lucia Aldred, Henrique Moura de Paula, Pedro Enrique Dorlhiac-Llacer
Acta Haematol (2010) 124 (2): 105–109.
Published Online: 19 August 2010
...Mariana Serpa; Israel Bendit; Fernanda Seguro; Flavia Xavier; Marcela Cavalcante; Daniel Steinbaum; Luciana Nardinelli; Vera Lucia Aldred; Henrique Moura de Paula; Pedro Enrique Dorlhiac-Llacer While chronic lymphocytic leukemia (CLL) and chronic myeloid leukemia (CML) are common diseases...
Acta Haematol (2010) 124 (1): 57–60.
Published Online: 09 July 2010
... from the skeleton by a humoral mediator. The latter mechanism is referred to as humoral hypercalcemia of malignancy (HHM). Frequent mediators of HHM are parathyroid hormone-related peptides (PTHrP). We report a patient with chronic lymphocytic leukemia and hypercalcemia induced by PTHrP. In contrast...
Monika Podhorecka, Piotr Klimek, Malgorzata Kowal, Sylwia Chocholska, Agnieszka Bojarska-Junak, Anna Dmoszynska
Acta Haematol (2010) 123 (3): 171–178.
Published Online: 11 March 2010
...Monika Podhorecka; Piotr Klimek; Malgorzata Kowal; Sylwia Chocholska; Agnieszka Bojarska-Junak; Anna Dmoszynska Chronic lymphocytic leukemia (CLL) is a heterogeneous disease with variable clinical course and prognosis. Therefore, the role of prognostic factors is very important, especially...
Acta Haematol (2010) 123 (2): 77–80.
Published Online: 23 December 2009
... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Chronic lymphocytic leukemia Small lymphocytic lymphoma Hepatocellular carcinoma Hepatitis C virus...
Olga A. Tsopra, Panos G. Ziros, Eleni D. Lagadinou, Argiris Symeonidis, Alexandra Kouraklis-Symeonidis, Eleni Thanopoulou, Maria K. Angelopoulou, Theodoros P. Vassilakopoulos, Gerassimos A. Pangalis, Nicholas C. Zoumbos
Acta Haematol (2009) 121 (4): 187–195.
Published Online: 26 May 2009
...Olga A. Tsopra; Panos G. Ziros; Eleni D. Lagadinou; Argiris Symeonidis; Alexandra Kouraklis-Symeonidis; Eleni Thanopoulou; Maria K. Angelopoulou; Theodoros P. Vassilakopoulos; Gerassimos A. Pangalis; Nicholas C. Zoumbos Background/Aims: Disease-related anemia in chronic lymphocytic leukemia (CLL...
Acta Haematol (1971) 45 (3): 181–191.
Published Online: 05 March 2009
...K. Bremer; T.M. Fliedner The labeling pattern of in vitro 3 H-cytidine labeled blood lymphocytes was studied after autotransfusion in 2 hematologically normal patients and in 6 patients with untreated chronic lymphocytic leukemia. An in vitro incubation time of 45 min results in a rapid loss...