... iron chelation treatment influenced ferritin levels (p = 0.002, Kruskal-Wallis test) since chelation with a single agent seems to increase the risk of a skin disease (p = 0.013, likelihood ratio method). Conclusively, serum ferritin can be evaluated as risk factor for generalized dermatoses...

...Yutaka Kohgo; Akio Urabe; Yurdanur Kilinç; Leyla Agaoglu; Krzysztof Warzocha; Koichi Miyamura; Lay Cheng Lim; Sabine Glaser; Candace Wang; Wieslaw Wiktor-Jedrzejczak Iron overload in transfusion-dependent patients with rare anemias can be managed with chelation therapy. This study evaluated...

... dilemma of an improbable failure of DFX chelation, the pathogenesis of this phenomenon remains to be clarified, thus further complicating the problem of ferritin specificity and its role in monitoring chelation efficacy and in adapting DFX dosage in a limited period of treatment. 12 08 2009 4 11...

...R. Galanello; S. Campus Iron overload is one of the major causes of morbidity in patients with thalassemia major. Deferiprone (DFP), an orally active iron chelator, emerged from an extensive search for new drugs to treat iron overload. Comparative studies have shown that at comparable doses...

...M.D. Cappellini; A. Taher Deferasirox is a once-daily oral iron chelator with established dose-dependent efficacy in both adult and pediatric patients with transfusional iron overload. The clinical development program has demonstrated the efficacy of deferasirox for up to 4.5 years of treatment...

...John-Paul Carpenter; Dudley J. Pennell The monitoring of chelation therapy is a very important part of the management of transfusion-dependent patients. Classical methods of monitoring iron loading are either unreliable or unable to detect important myocardial siderosis which can predispose...

...Syed Bilgrami; Ann Bartolomeo; Valerie Synnott; Frederick R. Rickles Patients with hemosiderosis who also suffer from coexistent anemia may be unable to tolerate frequent phlebotomies needed for depletion of body iron stores. Chelation therapy, an alternative approach, maybe unsuitable for some...

...Vilma Gabutti; Antonio Piga The improvement in survival and quality of life of iron-overloaded patients achieved by regular subcutaneous chelation has been extensively documented over the years. A review of the long-term results allows one to establish the following points: (1) with regular...

... to in the content or advertisements. β-Thalassaemia Chelation Iron overload Heart failure secondary to myocardial iron overload remains the commonest cause of death in thalassaemia major [ 1 ]. Conventional teaching dictates that iron-induced cardiomyopathy only occurs in the presence of severe...