... (GVHD) are the primary obstacles to a successful outcome. Methods: We conducted a retrospective study of HSCT in 29 children (median age at transplantation: 6 years) with Beta-thalassemia (β-TM) after the combined infusion of granulocyte colony-stimulating factor-primed bone marrow (G-BM) and cord blood...

...Russell K. Brynes; Raymond S.M. Wong; Maung M. Thein; Kalpana K. Bakshi; Paul Burgess; Dickens Theodore; Attilio Orazi Background: The long-term effects of eltrombopag on bone marrow (BM) reticulin and/or collagen deposition in previously treated adults with chronic immune thrombocytopenia (ITP...

...Imke Lustfeld; Bianca Altvater; Martina Ahlmann; Sandra Ligges; Peter Brinkrolf; Annegret Rosemann; Anja Moericke; Claudia Rossig Residual nonmalignant T cells in the bone marrow of patients with acute leukemias may be involved in active immune responses to leukemic cells. Here, we investigated...

...M.R. Parwaresch; L.-D. Leder; K.E.G. Dannenberg By a combined application of toluidine blue stain and naphthol AS-D chloroacetate esterase reaction on normal bone marrow smears metachromic and promyelocytic granules were demonstrated on the same cell. Precursors of basophils contain NASDCl-esterase...

... intervals on both peripheral and marrow blood.The results showed that circulating blasts in S-phase returned to the marrow and then passed back to the circulating compartment after division. Their half-live values was 22.1 h. Autoradiography Bone marrow Leukaemic cells Lymphoblastic leukaemia 5...

...D. Zurwehme; H.J. Mitzkat; B. Dommes Using a gel film technique 11 key enzymes of the energy metabolism were histochemically demonstrated in the bone marrow cells of healthy persons or patients suffering from non-haematological disorders. The enzyme activity was assessed by a semiquantitative...

...Y. Horn; D.C. Price A study was performed on the effect of testosterone on post-irradiation recovery of bone marrow and circulating granulocytes in the rat. Testosterone accelerated recovery of peripheral polymorphonuclear leukocytes, more so if therapy was initiated prior to irradiation. Increased...

...J. Haot; E.H. Betz; L.J. Simar; L. Revesz After sublethal irradiation, an immature lymphoid cell type with characteristic ultrastructure was found in the bone marrow and thymus of adult mice of different strains. Normally this cell type has only been detected in the embryo or new-born. Grafting...

...-irradiation. The cellularity of the femoral bone marrow, the weight of the spleen and the number of (endogenous) spleen colonies are elevated in animals anaesthetized using Avertin during exposure to doses of whole-body X-irradiation in the range between 400 and 850 rad, with a dose reduction factor of 1.2...

..., whereas site B should donate its iron preferentially to cells involved in the absorption and storage of iron. In the present study this hypothesis could be confirmed by in vitro experiments with various cell types. Iron transferrin preincubated with rat bone marrow cells donates less iron to rat bone...

...U. Sjögren; H. Thysell Bone marrow smears from 57 patients with chronic renal failure were morphologically analysed. In 55 patients on regular haemodialysis there was a slight ‘shift to the left’ and a significant eosinophilia within the granulopoiesis concurrently with slight megaloblastic changes...

...Yoram Cohen; Ruth Gershoni-Baruch; Chaim Lichtic 104 patients with various cancers, excluding malignant lymphoma and leukemia, underwent bone marrow biopsy using a Jamshidi needle, regular type. In 100 patients an adequate piece of bone marrow was obtained. In 24 patients metastases were detected...

...G. Cambiaghi; S. Paina In patients with cirrhosis, the etiocholanolone test showed a decrease in the bone marrow granulocyte reserve; in all the cases studied, the baseline counts of peripheral granulocytes were normal. The mechanisms leading to such a defect are explained. Acta haemat. 60: 291-295...

...U. Sjögren; L. Brandt Aspirates from bone marrow, spleen and liver were analyzed in 15 untreated patients with chronic myeloid leukaemia (CML). The proportion of erythroblasts was higher in the spleen and liver than in the bone marrow. An increased frequency of basophilic leucocytes was recorded...

...U. Kempgens; M. Mayer; S. Schlosshardt; U. Müller; W. Queisser Proliferation of bone marrow lymphoid cells of 8 healthy subjects and 7 patients with chronic renal insufficiency was compared using the cytophotometric measurement of the DNA content combined with 3 H-thymidine labelling in vitro...

...E. Magliulo; M. Gallina; D. Scevola; E. Concia In patients with HBAg-positive and HBAg-negative viral hepatitis the etiocholanolone test showed a decrease of the bone marrow granulocyte reserve at the height and, though at a lower degree, at the end of the disease. These results are discussed...

...U. Sjögren The mitotic indices of the granulopoietic precursor cells in the bone marrow of 3 untreated patients with acute eosinophilicmonocytic leukaemia were found to be significantly lower than those of 20 normals. The differences were found in the eosinophilic, the neutrophilic...

...U. Sjögren Aspirates from bone marrow, spleen and liver were analysed in 10 untreated patients with idiopathic myelofibrosis (MF). The proportion of erythroblasts was higher in the spleen and the liver than in the bone marrow. The mitotic indices of the erythropoietic precursor cells were subnormal...

...F. Chiuini; Delia Torre; G. Fanò; A. Viti The effects of an erythropoietin (Ep)-rich plasma fraction and of a commercial preparation of purified Ep (Step I) on the cyclic adenosine monophosphate (cAMP) levels of suspended rabbit bone marrow cells at different incubation times (up to 10 min) were...

...Danel O. Ho-Yen; Najma Saleem; Laura W. Fleming; William K. Stewart; Henry B. Goodall Bone marrow biopsies of 15 patients with chronic renal failure (CRF) were compared with those of a control group matched for age and sex. Using a point-counting method for assessing cellularity...