... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Acute leukemia (adult) Acute leukemia in childhood BCR-ABL Chronic myeloid leukemia The t(9;22)(q34;q11) Philadelphia chromosome (Ph...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Apoptosis BCR-ABL Chronic myeloid leukemia Gene expression Tyrosine kinase inhibitors alineferreira591...

... JAK2 are found in many BCR-ABL -negative myeloproliferative neoplasms. Preclinical results support that JAK2 inhibitors could show efficacy in treating chronic myeloproliferative neoplasms. JAK2 has also been postulated to play a role in BCR-ABL signal transduction. Therefore, inhibitors of JAK2...

..., Jinnai I, Bessho M: Successful treatment with imatinib mesylate in a case of minor BCR-ABL-positive acute myelogenous leukemia. Int J Hematol 2005;81:242–245. 7. Yamaguchi M, Konishi I: Successful treatment with imatinib mesylate for Philadelphia chromosome-positive refractory acute myeloid leukemia...

...), mutations of the BCR-ABL tyrosine kinase domain (TKD) and BCR-ABL splice variants may cause resistance to first- and second-generation tyrosine kinase inhibitors (TKIs) in chronic myelogenous leukemia (CML) and Philadelphia-positive (Ph+) acute lymphoid leukemia (ALL). Methods: Karyotyping and BCR-ABL TKD...

...Hege K. Vefring; Franz X.E. Gruber; Line Wee; Randi Hovland; Henrik Hjorth-Hansen; Tobias Gedde Dahl; Peter Meyer The BCR-ABL fusion gene represents the hallmark of chronic myelogenous leukemia (CML) and is derived from a translocation between chromosome 9 and 22. The majority of CML patients have...

... of crisis. RNA was isolated from formalin-fixed and paraffin-embedded tissue specimens for the polymerase chain reaction of bcr-abl. CML-type products were detected in the peripheral blood, but no bcr-abl products were found in the lymph nodes. These findings indicate a very rare case in which Hodgkin’s...

...A. Käbisch; L. Pérènyi; U. Seay; J. Lohmeyer; H. Pralle The BCR-ABL fusion gene is directly involved in the pathogenesis of chronic myeloid leukemia (CML). Specific inhibition of the BCR-ABL gene expression with antisense oligodeoxynucleotides has been shown to have profound effects on cell growth...

...John M. Goldman; Junia V. Melo The discovery of the BCR-ABL fusion gene on the Philadelphia (Ph) chromosome in 1985 was the start of a new era in understanding the molecular basis of hematologic malignancies. It provided the rationale for producing first imatinib and then a series of small...

..., instructions or products referred to in the content or advertisements. Apoptosis BAD BAX BCL2 BCL-X L BCL-X S BCR-ABL Chronic myelogenous leukemia Imatinib The BCR-ABL fusion gene product, BCR-ABL, is a constitutively activated tyrosine kinase, which is central to the pathogenesis...

... with BCR-ABL-positive chronic myelogenous leukemia in complete cytogenetic remission is revisited. Ten milliliters of PB is sufficient for processing on the day of blood collection whereas the use of only 5 ml PB may result in false-negative results. Standardization of preanalytical and analytical factors...

... chromosome in patients treated by interferon-α (IFN-α) or allogeneic stem cell transplantation. The use of fluorescence in situ hybridisation (FISH) techniques to detect the BCR-ABL fusion gene in Ph-positive leukaemia cells increased the sensitivity of cytogenetic studies to some degree. In the last 10...