...Ruham Alshiekh-Nasany; Dan Douer Introduction: Similar to pediatric regimens, multiple doses of L -asparaginase (PEG-Asp) are being increasingly used in adults with newly diagnosed acute lymphoblastic leukemia (ALL) with promising results. One of the most common side effects of the drug in adults...

... and asparaginase, with very promising preliminary results. Discovering new mutations in AYA ALL will help stratify patients into risk subgroups and identify targets for novel agents. This, together with fine-tuning pediatric chemotherapy principles will hopefully finally decrease the cure rate gap between children...

...R. Schrek; K.V. Batra; J.S. Holcenberg; J. Roberts; W.C. Dolowy The transformation of lymphocytes by phytohemagglutinin and the uptake of thymidine by DNA are completely inhibited by 17 mlU/ml L-glu taminase GA:1.2. The transformation is also inhibited by 1,700 mlU EC2 L-asparaginase/ml, which...

...J. Mirecka; G. Astaldi; Z. Szmigiel; J. Lisiewicz; M. Wazewska-Czyzewska The possibility of direct release of immunoglobulin from the erythrocyte surfaces due to the break of the erythrocyte-immunoglobulin binding after the i.v. administration of L-asparaginase has been shown in patients...

...Giovanni Luca Pagliardi; Vilma Gabutti; Felice Gavosto The effect of L-asparaginase on various acute human lymphoblastic leukemia cell populations was evaluated in an investigation of its mechanism of action with respect to the blast cell cycle and the growth of the leukemic cell population...

...Ellen A. Leinonen Bone marrow cells of 8 patients with acute lymphocytic leukemia were studied by cytochemical and autoradiographic methods for the synthesis of nucleic acids in the presence or absence of L-asparaginase. The cultures included thymidine for DNA or uridine for RNA metabolism...

... with or without sequential asparaginase (ASNase) were investigated in order to evaluate liver toxicity and a possible decrease in antithrombin III (AT III) plasma level. AT III was found decreased only in patients who received ASNase, whereas HIDARAC alone did not influence AT III levels. It is pointed out...