...Yingjian Si; Rongmu Luo; Maoquan Qin; Zhenlan Du; Xiaomei Zhang; Ya Wang; Wei Chen; Wenjing Gu; Guosheng Xing; Lingsong Dou; Wei Cao; Zhichun Feng Introduction: This retrospective study aimed to compare a range of conditioning regimens in children with severe aplastic anemia (SAA) undergoing...

...Jingke Tu; Hong Pan; Ruonan Li; Zhe Wang; Yu Lian; Weiwang Li; Jun Shi; Liwei Fang Objectives: PNH clones, also aptly called “escape clones,” are evidence of acquired immune-mediated bone marrow failure and have a high prevalence in patients with aplastic anemia (AA). Several studies have reported...

...Hanny Al-Samkari; Katayoon Goodarzi Eltrombopag is a thrombopoietin receptor agonist frequently used to manage immune thrombocytopenia and aplastic anemia. At the high doses used for aplastic anemia, but not the doses used for immune thrombocytopenia, eltrombopag can cause reddish-brown...

...Xiao-Fan Zhu; Hai-Long He; Shun-Qing Wang; Jing-Yan Tang; Bing Han; Dong-Hua Zhang; Li-Qiang Wu; De-Pei Wu; Wei Li; Ling-Hui Xia; Huan-Ling Zhu; Feng Liu; Hong-Xia Shi; Xi Zhang; Fang Zhou; Jian-Da Hu; Jian-Pei Fang; Xie-Qun Chen; Tie-Zhen Ye; Ying-Min Liang; Jie Jin; Feng-Kui Zhang Aplastic anemia...

...Shao-xue Ding; Tong Chen; Ting Wang; Chun-yan Liu; Wen-li Lu; Rong Fu Objectives: This meta-analysis aimed to evaluate the risk of clonal evolution of granulocyte colony-stimulating factor (G-CSF) in acquired aplastic anemia (AA), and whether the use of G-CSF increases the occurrence of secondary...

...Ilana Levy; Ruth Laor; Nizar Jiries; Jacob Bejar; Aaron Polliack; Tamar Tadmor Acquired amegakaryocytic thrombocytopenia (AAT), a rare entity characterized by severe thrombocytopenia and the absence of megakaryocytes in the bone marrow, may mimic or precede the diagnosis of aplastic anemia (AA...

...Yali Du; Zhangbiao Long; Miao Chen; Bing Han; Bo Hou; Feng Feng Background: This study focuses on the iron overload (IOL) of patients with transfused aplastic anemia (AA) or a low/intermediate-1 risk of myelodysplastic syndrome (MDS). Methods: Ninety-two AA or MDS patients with IOL were...

... transplant recipients. Several fatal cases of EBV-LPD have been reported in aplastic anemia (AA) patients receiving immunosuppressive therapy (IST) with antithymocyte globulin (ATG) plus cyclosporine A (CsA), but no appropriate prophylactic or therapeutic strategy has been established. Herein, we describe...

...-identical familial donor (haploFD) using a busulfan-fludarabine-antithymocyte globulin conditioning regimen for severe aplastic anemia (sAA) and hypoplastic myelodysplastic syndrome. For the comparison between a haploFD and an alternative donor (AD; matched unrelated or partially matched donor) for sAA...

... deferasirox efficacy and safety in patients with myelodysplastic syndromes (MDS), aplastic anemia (AA) or other rare anemias. A 1-year, open-label, multicenter, single-arm, phase II trial was performed with deferasirox (10-40 mg/kg/day, based on transfusion frequency and therapeutic goals), including...

... was 77.6%. The cohort of patients was divided into subcategories of classic PNH, PNH/aplastic anemia (AA), and subclinical PNH (PNH-sc)/AA based on the recently proposed PNH working clinical classification. We found that patients with classic PNH and PNH/AA had larger PNH clones and many more parameters...

...Amy E. DeZern; Eva C. Guinan Adolescent and young adult patient presentations of aplastic anemia require a particular perspective on both diagnosis and treatment. This unique age group necessitates a thorough diagnostic evaluation to ensure the etiology, acquired or inherited, is sufficiently...

... (ICT) is important in patients with aplastic anemia (AA) who require blood transfusions as supportive management. With the introduction of the oral iron chelator deferasirox, ICT has become more widely available and feasible. We studied 4 adult AA patients who had transfusion-induced iron overload...

...Jan Lakota; Annika Lanz; Maria Dubrovcakova; Barbora Jankovicova; Asensio Gonzalez; Martin Stern Background/Aims: Antibodies against carbonic anhydrase (CA) have been detected in patients with an aplastic anemia (AA)-like syndrome after autologous stem cell transplantation. Methods: We analyzed...

...Chun Chen; Suying Lu; Min Luo; Bihong Zhang; Lulu Xiao To investigate the correlations between polymorphisms of human leukocyte antigen (HLA)-A, HLA-B and HLA-DRB1 alleles and childhood susceptibility to aplastic anemia (AA), 80 children with AA were investigated. Among the 80 children, 74 had...

... there is pharmacological immunosuppression including antithymocyte globulin. We herein present an unusual case of EBV associated with LPD (EBV-LPD) in which LPD occurred 3 weeks after the use of rabbit antithymocyte globulin administered for severe hepatitis-associated aplastic anemia; the patient died of fulminant...

...Anat Gafter-Gvili; Ron Ram; Pia Raanani; Ofer Shpilberg Aplastic anemia is a rare bone marrow failure disorder. Allogeneic hematopoietic cell transplantation (alloHCT) and immunosuppressive therapy (IST) are the main therapeutic modalities currently used to treat patients with aplastic anemia...

... Wahlin; Anna Pegoraro; Jakob Passweg Background: Aplastic anemia (AA) is rarely described after a diagnosis of autoimmune disease (aID). Aims: To assess the prevalence of prior aID in patients with AA recorded in the registry of the European Group for Blood and Marrow Transplantation (EBMT...

... and peripheral blood findings indicated he had severe aplastic anemia (AA). A whole-body CT scan and Ga scintigraphy revealed no abnormal findings. Antithymocyte globulin and cyclosporine A (CyA) were administered and he got transfusion independently. In September 2004, he complained of abdominal fullness...

...G. Corneo; M. Cortellaro; A.T. Maiolo Some clinical aspects in 18 patients affected by aplastic anemia are considered. Liver involvement might be due to serum hepatitis, drug toxicity and possibly to the same etiologic factors causing aplastic anemia. In some patients a decreased glucose tolerance...