...), and antithymocyte globulin (ATG) and recovered completely. EBV infection is known to cause a variety of benign and malignant hematologic disorders, including bone marrow failure. However, to the best of our knowledge, this is the first case report of EBV-associated AAT. Treatment options for AAT are still not well...

... there is pharmacological immunosuppression including antithymocyte globulin. We herein present an unusual case of EBV associated with LPD (EBV-LPD) in which LPD occurred 3 weeks after the use of rabbit antithymocyte globulin administered for severe hepatitis-associated aplastic anemia; the patient died of fulminant...

... transplantation Antithymocyte globulin Aplastic anemia Cyclosporine Hematopoietic growth factors Meta-analysis Systematic review Aplastic anemia is characterized by pancytopenia and hypoplastic bone marrow (BM) [ 1 ]. It is a rare disorder with an incidence rate estimated at around two per million...

... of antithymocyte globulin (ATG) and cyclosporine (CsA). Methods: We performed a systematic review and meta-analysis of all randomized controlled trials that compared ATG and CsA to ATG alone as first-line treatment for patients with severe and nonsevere aplastic anemia. The Cochrane Library, Medline, conference...

...X. López-Karpovitch; M.E. Zarzosa; M.R. Cárdenas; J. Piedras The short-term effect of a domestically produced equine antithymocyte globulin (ATG) was analyzed in 6 patients with acquired severe aplastic anemia (AA). All patients received 5 doses of ATG every other day in a 60-min intravenous...

... and complete engraftment. An alternative immunosuppressive treatment was attempted as a second bone marrow transplantation could not be performed. Consecutive immunosuppressive courses with antithymocyte globulin, antithymocyte globulin plus ciclosporin A and ciclosporin A alone elicited good but transient...

.../kg/day) of a high-potency antithymocyte globulin (ATC) produced in Mexico, shown to have at least a 10-fold potency as compared with other globulins of commercial sources. Patients received ATG within a 10-day period, every other day (5 doses) at a dose of 1 mg/kg/day (4 courses), 2 mg/kg/day (12...

... with antithymocyte globulin (ATG) which induced acute exacerbation of MS. Despite the low total dose of ATG (31.5 mg/kg), complete remission of SAA was obtained. Two other patients developed thyroid disorders, 42 and 106 months after successful immunosuppression with ATG/high-dose methylprednisolone. IHT...

... with immunosuppression (IS), 20 with antithymocyte globulin and cyclosporin A (ATG + CyA) and 6 with CyA, whereas 7 individuals were given only anabolic androgens. In the patients treated with IS a complete remission was achieved in 12 and a partial remission in 6, the overall response rate being 69%. The 5,729-day...

...-mediated mechanisms. Immunosuppressive therapy for SAA using cyclosporin A (CsA) alone or concurrent CsA and antithymocyte globulin (ATG) failed to induce a hematological response. The intensity of the autoantibodies, however, partially decreased during this period. In addition, the CD4/CD8 ratio...

.... Antithymocyte globulin Aplastic anaemia Immunosuppression Prior to the availability of antithymocyte globulin (ATG) and bone marrow transplantation (BMT) as therapeutic tools to treat patients with aplastic anaemia (AA), 50% of patients with AA died within 4–6 months [ 1 ]. Now for the majority, AA...