...Yuchen Liu; Yi Ning; Gabriel Ghiaur; Ashkan Emadi Introduction: Acute promyelocytic leukemia (APL) is genetically characterized by the fusion of promyelocytic leukemia (PML) gene with retinoic acid receptor alpha (RARα) resulting from a t(15;17)(q24;q21) chromosomal translocation. An infrequent...

... of glomerulonephritis and acute myeloid leukemia have been reported in the literature. We describe the first case of a genetically diagnosed acute promyelocytic leukemia presenting with nephrotic range proteinuria that resolved with induction therapy with ATRA and ATO and performed a comprehensive review...

...Calogero Lauricella; Rosa Greco; Valentina Mancini; Valentina Motta; Anna Ciraolo; Gabriella De Canal; Elena De Paoli; Giulia Paglino; Valentina Guido; Emanuela Bonoldi; Silvio Veronese; Silvia Soriani More than 95% of patients with acute promyelocytic leukemia (APL) are characterized...

... transcriptase catalytic subunit (TERT) and an RNA template (TERC) . Very short telomeres and loss-of-function mutations in the TERT and TERC genes have been reported in acute myeloid leukemia, but the role of telomeres in acute promyelocytic leukemia (APL) has not been well established. We report the results...

...Hongbing Ma; Jing Yang Background: This study aimed to compare the curative effects of the combination therapy of all- trans -retinoic acid (ATRA) and arsenic trioxide (ATO, As 2 O 3 ) with ATRA monotherapy on newly diagnosed acute promyelocytic leukemia (APL). Methods: The studies were retrieved...

...Eytan M. Stein; Martin S. Tallman Acute promyelocytic leukemia (APL) is a rare subtype of AML characterized by a reciprocal balanced translocation between chromosomes 15 and 17 that fuses the PML gene with the RARα gene and leads to the leukemic phenotype. Although best described in large clinical...

... receptor is mutated. Implications that Gli proteins are molecular targets of arsenic trioxide (ATO) action prompted us to investigate the expression of Hh signaling in acute promyelocytic leukemia (APL) and the influence of ATO on the Hh signaling pathway in APL. Methods: Quantitative real-time reverse...

...Xing-li Zou; Ke Zeng; Li-ping Xie; Lin Wang; Min Chen; Ting Liu; Ting Niu Extramedullary relapse is a rare phenomenon in patients with acute promyelocytic leukemia (APL), especially that derived from urogenital systems like the testicles. In this report, we describe an APL patient who had received...

...Hung Chang; Ming-Chung Kuo; Lee-Yung Shih; Jin-Hou Wu; Tung-Liang Lin; Po Dunn; Tzung-Chih Tang; Yu-Shin Hung; Po-Nan Wang Patients with acute promyelocytic leukemia (APL) are prone to both bleeding and thrombosis. The bleeding complications are well known. In contrast, APL-associated thrombosis...

...Mingjuan Liu; Ji Liu; Lihui Liu; Li Yu; Bing Shi; Liping Ye; Yongqing Zhang; Hu Chen Acute myeloid leukemia (AML) is a rare complication observed after liver transplantation and only a handful of cases have been reported until now. We report a case of acute promyelocytic leukemia (APL) after liver...

... and apoptosis under certain experimental conditions. However, the detailed mechanism by which bufalin induces the apoptosis of acute promyelocytic leukemia cells is largely unexplored. Methods: The acute promyelocytic leukemia cell line NB4 was treated with bufalin, then the proliferation was evaluated by cell...

...Ofir Wolach; Moshe Yeshurun; Ninette Amariglio; Ofer Shpilberg; Pia Raanani Acute promyelocytic leukemia (APL) may appear rarely as a late complication of the treatment of other primary cancers. Therapy-related APL (tAPL) differs from de novo APL in epidemiological and clinical parameters...

...Donatella Ruggero; Michele Baccarani; Anna Guarini; Luigi Gugliotta; Marco Gobbi; Paolo Ricci; Alfonso Zaccaria; Francesco Lauria; Ivana Tomasini; Mauro Fiacchini; Maria Alessandra Santucci; Sante Tura Acute promyelocytic leukemia (APL) was diagnosed in 13 of 84 adult patients (15.4%) with acute...

...A. Cantù Rajnoldi; M. Ferrari; G. Cambiaghi; G.C. Secchi; C. Uderzo; G. Masera A variant form of acute promyelocytic leukemia has been recently described, characterized by a particular morphological picture associated with severe disseminated intravascular coagulation, with hyperleukocytosis...

... to in the content or advertisements. Acute promyelocytic leukemia Embolization Hemorrhage Case Reports Acta haemat. 70: 119-121(1983) © 1983 S. K argerA G . Basel oooi-5792/83/0702-0119$ 2.75/0 Successful Embolization for Uterine Hemorrhage in a Patient with Acute Promyelocytic Leukemia Shuichi...

...Kenji Okajima; Shin Koga; Hiroaki Okabe; Masayasu lnoue; Kiyoshi Takatsuki Plasma samples from patients with disseminated intravascular coagulation (DIC) associated with acute promyelocytic leukemia (APL) exhibited higher levels of the D-fragment of fibrin and fibrinogen degradation products [FDP(D...

...Amar Das Gupta; Rupa S. Sapre; Ajit S. Shah; Suresh H. Advani; Chandrika N. Nair The leukemic promyelocytes in 37 cases of acute promyelocytic leukemia (APML; FAB, M 3 ) were examined for their cytochemical property. Thirty-two cases (86%) showed strong myeloperoxidase (MPO), chloroacetate esterase...

...Eric.J Feldman; Zalmen.A Arlin; Tauseef Ahmed; Abraham Mittelman; Joao.L Ascensao; Carmelo.A Puccio; Nancy Coombe; Paul Baskind Forty-six induction courses were administered to 32 patients with acute promyelocytic leukemia. There were 28 males and 18 females with a median age of 39.5 (range 19–68...

...P. Fenaux All- trans -retinoic acid (ATRA) has demonstrated in vivo and in vitro that it could differentiate leukemic cells in acute promyelocytic leukemia (APL). ATRA yields complete remission (CR) rates of approximately 90% in newly diagnosed and first relapsing APL, in APL resistant to one...

...Yoshinori Shimamoto; Kenji Suga; Masaya Yamaguchi; Kazutaka Kuriyama; Masao Tomonaga A 61-year-old man with acute promyelocytic leukemia (APL) is described in whom some leukemic promyelocytes contained granules similar to those of basophils, and hyperhistaminemia developed after treatment with all...