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Keywords: Acute lymphoblastic leukemiaClose
Acta Haematol 1–13.
Published Online: 03 November 2022
...Li Zhou; Zhe Shan; Jiangsha Fan Introduction: Acute lymphoblastic leukemia (ALL) is a common hematologic neoplastic disease. This study discussed the effect of extracellular vesicles (EVs) released from bone marrow mesenchymal stem cells (BMSCs) on ALL cells and the mechanism. Methods: BMSCs-EVs...
Taro Edahiro, Noriyasu Fukushima, Tatsuya Otani, Masahiro Nakamori, Kazuo Nakamichi, Ren Chishaki, Keita Fujino, Tatsuji Mino, Tetsumi Yoshida, Sayaka Sugihara, Masatoshi Nishizawa, Tatsuo Ichinohe
Acta Haematol (2022) 145 (6): 655–661.
Published Online: 27 July 2022
... and refractory acute lymphoblastic leukemia (ALL) than conventional chemotherapy. But, blinatumomab suppresses humoral immunity due to long-lasting B-cell depletion during and after the treatment. The development of PML involves cellular immunity and impairment of humoral immunity. Although few cases...
Hiroaki Goto, Chitose Ogawa, Hiroatsu Iida, Keizo Horibe, Iekuni Oh, Satoru Takada, Yoshinobu Maeda, Hironobu Minami, Yasuhiro Nakashima, Joan D. Morris, William Kormany, Yuqi Chen, Toshihiro Miyamoto
Acta Haematol (2022) 145 (6): 592–602.
Published Online: 05 July 2022
...) molecule, was evaluated in an expansion cohort of the phase 1b/2 study (NCT02412306) in Japanese adult ( n = 14) and pediatric ( n = 17) patients with relapsed/refractory Philadelphia-negative B-cell precursor (BCP) acute lymphoblastic leukemia (ALL). Materials and methods: Globally recommended...
Pierre Peterlin, Alice Garnier, Amandine Le Bourgeois, Maxime Jullien, Amélie Seguin, Marion Eveillard, Marie-Christine Béné, Thierry Guillaume, Patrice Chevallier
Acta Haematol (2022) 145 (5): 537–541.
Published Online: 20 June 2022
... is very rare and mostly fatal. Treatment recommendations for such a complication are not yet established. Here, we report the dramatic recovery of HLH/MAS following tisagenlecleucel infusion in a young patient with relapsed acute lymphoblastic leukemia using etoposide phosphate (EP). We propose...
Elena Parovichnikova, Vera Troitskaya, Andrey Sokolov, Olga Gavrilina, Zalina Akhmerzaeva, Larissa Kuzmina, Galina Kliasova, Julia Chabaeva, Sergey Kulikov, Sergey Bondarenko, Olga Baranova, Olga Samoilova, Kamil Kaplanov, Natalia Minaeva, Valeriy Savchenko, Russian Acute Lymphoblastic Leukemia Group
Acta Haematol (2020) 143 (2): 131–139.
Published Online: 09 October 2019
...Elena Parovichnikova; Vera Troitskaya; Andrey Sokolov; Olga Gavrilina; Zalina Akhmerzaeva; Larissa Kuzmina; Galina Kliasova; Julia Chabaeva; Sergey Kulikov; Sergey Bondarenko; Olga Baranova; Olga Samoilova; Kamil Kaplanov; Natalia Minaeva; Valeriy Savchenko; Russian Acute Lymphoblastic Leukemia...
Firas El Chaer, Noa G. Holtzman, Edward A. Sausville, Jennie Y. Law, Seung Tae Lee, Vu H. Duong, Maria R. Baer, Rima Koka, Zeba N. Singh, Nancy M. Hardy, Ashkan Emadi
Acta Haematol (2019) 141 (2): 107–110.
Published Online: 29 January 2019
...Firas El Chaer; Noa G. Holtzman; Edward A. Sausville; Jennie Y. Law; Seung Tae Lee; Vu H. Duong; Maria R. Baer; Rima Koka; Zeba N. Singh; Nancy M. Hardy; Ashkan Emadi Adults with relapsed or refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL) treated with conventional chemotherapy have...
Acta Haematol (2018) 140 (4): 209–214.
Published Online: 19 October 2018
...Boaz Nachmias; Adir Shaulov; Moshe E. Gatt; Michael Shapira; Alexander Gural The treatment of relapsed/refractory acute lymphoblastic leukemia (RR-ALL) presents a true clinical challenge. In 2012, a protocol combining bortezomib, dexamethasone, asparaginase, doxorubicin, and vincristine...
Acta Haematol (2016) 135 (4): 208–210.
Published Online: 04 February 2016
...Ruham Alshiekh-Nasany; Dan Douer Introduction: Similar to pediatric regimens, multiple doses of L -asparaginase (PEG-Asp) are being increasingly used in adults with newly diagnosed acute lymphoblastic leukemia (ALL) with promising results. One of the most common side effects of the drug in adults...
Acta Haematol (2014) 132 (3-4): 264–273.
Published Online: 10 September 2014
...Patrick W. Burke; Dan Douer The cure rate of acute lymphoblastic leukemia (ALL) in children is 80%, compared to less than half in adults. A major proportion of this cure rate drop occurs in adolescents and young adults (AYAs). The age range defining this population varies between studies...
Jae-Sook Ahn, Deok-Hwan Yang, Sung-Hoon Jung, Je-Jung Lee, Inho Kim, Seonyang Park, Joo Seop Chung, Ho-Jin Shin, Dae-Young Kim, Kyoo-Hyung Lee, Joon Ho Moon, Sang Kyun Sohn, Ik-Chan Song, Deog-Yeon Jo, Young Don Joo, Korean Society of Hematology Adult ALL Working Party
Acta Haematol (2014) 133 (1): 91–97.
Published Online: 23 August 2014
... is a conventional agent for relapsed or refractory acute lymphoblastic leukemia (ALL). However, an effective combination with other drugs and a feasible dosage has not been identified. A retrospective study of 46 patients with relapsed or refractory ALL was conducted to determine the efficacy of mitoxantrone...
Imke Lustfeld, Bianca Altvater, Martina Ahlmann, Sandra Ligges, Peter Brinkrolf, Annegret Rosemann, Anja Moericke, Claudia Rossig
Acta Haematol (2013) 131 (1): 28–36.
Published Online: 19 December 2013
... the phenotypic signature of T cells present at diagnosis in 39 pediatric patients with acute lymphoblastic leukemia (ALL) treated within standardized ALL-BFM study protocols. Previously described age associations of lymphocyte subpopulations in the peripheral blood of healthy children were reproduced in leukemic...
Acta Haematol (2013) 130 (3): 188–191.
Published Online: 11 June 2013
... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Precursor B cell Acute lymphoblastic leukemia Immunophenotype Surface...
Acta Haematol (2013) 129 (4): 207–214.
Published Online: 15 May 2013
... Acute lymphoblastic leukemia Molecular mechanism Bortezomib Acute lymphocytic leukemia (ALL) is a malignant disorder that originates from one single hematopoietic precursor committed to the B cell or T cell lineage; 80–85% of ALL are of B-cell lineage (B cell precursor ALL, BCP-ALL) and 15...
Danuta Januszkiewicz-Lewandowska, Karina Nowicka, Jolanta Rembowska, Marta Fichna, Magda Żurawek, Katarzyna Derwich, Jerzy Nowak
Acta Haematol (2013) 129 (4): 232–237.
Published Online: 11 January 2013
... could suggest increased expression of HERV-K in leukemic cells. To elucidate the role of endogenous retroviruses in leukemogenesis, studies were undertaken to assess env gene expression of HERV-K and HERV-W in childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). Results...
Snjezana Janjetovic, Ulrike Bacher, Thomas Haalck, Melanie Janning, Carsten Bokemeyer, Walter Fiedler
Acta Haematol (2013) 129 (2): 121–125.
Published Online: 28 November 2012
... risk for developing acute lymphoblastic leukemia and acute myeloid leukemia (AML). Case Report: A 33-year-old male XP patient was diagnosed with acute megakaryoblastic leukemia with a complex karyotype. He received standard induction chemotherapy with cytarabine and daunorubicin. After the first cycle...
Yesim Oymak, Yavuz Dodurga, Aysen Turedi, Yontem Yaman, Gulcihan Ozek, Ozgur Carti, Burcak Tatlı Gunes, Esin Erbudak, Ergul Berber, Cıgır Biray Avci, Canan Vergin
Acta Haematol (2012) 128 (2): 73–76.
Published Online: 06 June 2012
... to in the content or advertisements. Acute lymphoblastic leukemia Leukemogenesis Poor prednisolone response URG4 Acute lymphoblastic leukemia (ALL) is the most common childhood malignant disease. Variations in the expression level of the cell cycle genes including cyclins, cyclin-dependent...
Claudio Carneiro Borba, Maria de Lourdes Chauffaille, Sabri Saeed Sanabnai, Juliana Folloni Fernandes, Cristina Aiko Kumeda, Elvira Deolinda Rodrigues Pereira Velloso, Katia Jarandilha dos Santos, Marcia Puato Vieira Pupim, Nelson Hamerschlak, Vicente Odone Filho, Israel Bendit
Acta Haematol (2012) 127 (3): 165–169.
Published Online: 01 February 2012
..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Acute lymphoblastic leukemia Chromosomal translocation Karyotyping...
Emmanouel S. Hatzipantelis, Miranda Athanassiou-Metaxa, Nikolaos Gombakis, Vaso Tzimouli, Anna Taparkou, Vasiliki Sidi-Fragandrea, Vasilia Garipidou, Theothotis Papageorgiou, Drosia Kleta, Dimitrios E. Koliouskas, Fani Athanasiadou-Piperopoulou
Acta Haematol (2011) 125 (3): 130–135.
Published Online: 11 December 2010
... with acute lymphoblastic leukemia (ALL) can result from the disease itself, from treatment, or from other conditions (e.g. sepsis). The aim of this study was to determine the levels of markers of endothelial activation in children with ALL and to assess their potential prognostic value. Fifty-two children...
Acta Haematol (2009) 122 (4): 216–220.
Published Online: 29 October 2009
...Reyad Dada; Stefan Wilop; Edgar Jost; Oliver Galm; Nikolaus Gassler; Rainhardt Osieka Infiltration of the liver with consecutive severe dysfunction is rarely seen in adult acute lymphoblastic leukemia (ALL). We describe a case of a 32-year-old woman with severe icterus, thrombocytopenia...
Acta Haematol (2009) 121 (1): 56–62.
Published Online: 02 April 2009
...Mehmet Akif Ozdemir; Musa Karakukcu; Turkan Patiroglu; Yasemin Altuner Torun; Mehmet Kose Introduction: The standard management of childhood acute lymphoblastic leukemia with hyperleukocytosis is unclear and its treatment has focused on prompt leukocytoreduction. Cytoreductive therapies have been...