... at our tertiary center between 2007 and 2017 and diagnosed as heterozygotes for the –α 3.7 deletion. Additional α-thalassemia mutations, iron deficiency anemia, and β-thalassemia were ruled out. Laboratory parameters were compared to age- and sex-matched reference values. Results: The –α 3.7 carriers had...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. α-Thalassemia Systolic function Diastolic function Ferritin Iron overload Anemia The α-thalassemias arise from deletions or mutations...

...Yu Yang; Dong-Zhi Li Nondeletional hemoglobin (Hb) H disease is caused by a deletion of both α-globin genes on one chromosome 16 and of an α + -thalassemia point mutation on the other chromosome 16. Patients with nondeletional Hb H disease are usually more anemic, more symptomatic, and are often...

...Yu Yang; Dong-Zhi Li A fetus at risk for α-thalassemia presented with cardiomegaly without evidence of anemia. Invasive testing demonstrated the diagnosis of homozygous α-thalassemia-1 with a normal-range hemoglobin (Hb) level. We suggest that in the prenatal detection of homozygous α-thalassemia-1...

...Birol Guvenc; Sule Menziletoglu Yildiz; Ferda Tekinturhan; Suleyman Dincer; Inci Akyuzluer; Secaatin Okten; Hakan Erkman Background/Aim: α-Thalassemia (α-thal) is a widespread genetic disorder throughout the world caused primarily by reduced synthesis of the α-globin chains, and it has been found...

...Jingzhong Liu; Ning Tang; Quanzhang Liu; Lirong Wang; Han Han; Ren Cai; Xiaoyi Wu; Bai Xiao The prevailing cause of α-thalassemia in Southeast Asia is the presence of 3 deletion mutations in the α-globin genes (–SEA, –α 3.7 and –α 4.2 ). Current detection methods include gap polymerase chain...

...A.P. Gelpi The percentage of Hb S in hemolysates from 109 Saudi Arab males was found to range from 18–47%, with a mean of 33%, an obvious mode at 32–34% and clear skewing of the overall pattern toward lower values. A tentative explanation of this finding is the concurrence of the α-thalassemia...

... which contained more than 0.5% Hb Bart’s. These findings suggest that elevated Hb Bart’s levels in the Algerian population are due to the presence of α-thalassemia. Acta haemat. 65: 240-246 (1981) Hemoglobin Bart s in Northern Algeria 7. Henni", D. Bachir", P. Tabone", P. Jurdic", J. Godet'1, P. Colonna...

... heterozygotes for Hb Hasharon and β -Thalassemia from 43 apparently unrelated families living in the province of Rovigo (northern Italy). Biosynthetic studies are also reported. The data strongly suggest the presence of an α -thalassemia-2 determinant closely linked to the α Hasharon -chain locus. Selective...

...P. Tabone; T. Henni; M. Belhani; P. Colonna; G. Verdier; J. Godet A case of Hb H disease from Algeria was studied at the genetic and molecular level in order to delineate the pattern of α-thalassemia in the Mediterranean population. The family study indicated that both parents had the hematological...

... in the blood for the remaining 2. The decrease in the relative synthesis of α-globin on erythroid cell maturation may relate to the molecular basis of α-thalassemia in the Middle East. Acta haemta. 64: 136-140 (1980) Balanced Bone Marrow Globin Synthesis in Mideastern a-Thalassemia R. Zaizov, M. Steinherz, B...

... studies and globin chain synthesis analysis (23 subjects). The α/ β ratio of 0.70 + 0.10 was the same as in obligate α -thalassemia -1 ( α -thal) carriers. Hb H inclusion bodies studies were found to be a reliable test for α -thal trait identification, resulting positive in approximately 70% of suspected...

... fragment. Mild hematological alterations were present. These data indicate that also in the Cuban population the α G Philadelphia locus is linked to a deletional α -thalassemia 27 09 1985 21 10 1985 25 2 2009 © 1985 S. Karger AG, Basel 1985 Copyright / Drug Dosage / Disclaimer...

...S. Daenen; A.L. Reese; F.K. Kutlar; T.H.J. Huiman Detailed hematological and fetal hemoglobin data as well as results from gene mapping analyses are reported for nine members of an Indonesian-Dutch family. An α -thalassemia-1 heterozygosity (Southeast Asian type) was present in five subjects...

... α -Thalassemia Acta haemat. 73: 181-182(1985) © 1985 S. Karger AG, Basel 0001-5792/85/0733-0181 $ 2.75/0 Priapism in Association with Sickle Cell Anemia in Saudi Arabia1 Baker Al-Awamy, Saud A. Taha, Mahtab A. Naeem Sickle Cell Anemia Group, King Faisal University, Dammam, Saudi Arabia Key Words...

... comparable to those seen in patients with a homozygosity for the -29 mutation or with the combination of this β + -thalassemia and Hb S. An α-thalassemia-2 heterozygosity (-3.7 kb deletion) was present in 2 patients. Their hematological data were improved over those for the patients with four α globin genes...

...Hong-Wen Peng; Kong-Bung Choo; Chao-Hung Ho; Ming-Shyen Yen; Wan-Ying Liung; Chung-King Lin; Zaw-Ling Yang; Heung-Tat Ng; King-Nien Ching; Shou-Hwa Han In a gene mapping study on 217 newborn babies in Taiwan with α- and ζ-globin probes, we have observed 4 cases (1.84%) of α-thalassemia-2...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. α-Gene deletion HbH disease α-Thalassemia Case Report Acta Haematol 1992;87:145-147...

... in the 20/20 group and the highest in the 3/3 group. Female SS patients with haplotypes 19/19 have higher Hb F levels than their male counterparts; the same was observed for the patients with the 19/3 haplotype combination but not for those with the 20/3 haplotype combination. A concomitant α-thalassemia-2...

... α-thal trait did not have severe recurrent infections and none had gallstones. The high frequencies of the Saudi Arabia/India βs haplotype and α-thalassemia trait contribute to the mild nature of SS disease among Kuwaiti Arabs comparable to that in eastern Saudi Arabia. 29 08 1995 11 12...