... at our tertiary center between 2007 and 2017 and diagnosed as heterozygotes for the –α 3.7 deletion. Additional α-thalassemia mutations, iron deficiency anemia, and β-thalassemia were ruled out. Laboratory parameters were compared to age- and sex-matched reference values. Results: The –α 3.7 carriers had...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. α-Thalassemia Systolic function Diastolic function Ferritin Iron overload Anemia The α-thalassemias arise from deletions or mutations...

...Yu Yang; Dong-Zhi Li Nondeletional hemoglobin (Hb) H disease is caused by a deletion of both α-globin genes on one chromosome 16 and of an α + -thalassemia point mutation on the other chromosome 16. Patients with nondeletional Hb H disease are usually more anemic, more symptomatic, and are often...

...Yu Yang; Dong-Zhi Li A fetus at risk for α-thalassemia presented with cardiomegaly without evidence of anemia. Invasive testing demonstrated the diagnosis of homozygous α-thalassemia-1 with a normal-range hemoglobin (Hb) level. We suggest that in the prenatal detection of homozygous α-thalassemia-1...

...Birol Guvenc; Sule Menziletoglu Yildiz; Ferda Tekinturhan; Suleyman Dincer; Inci Akyuzluer; Secaatin Okten; Hakan Erkman Background/Aim: α-Thalassemia (α-thal) is a widespread genetic disorder throughout the world caused primarily by reduced synthesis of the α-globin chains, and it has been found...

...Jingzhong Liu; Ning Tang; Quanzhang Liu; Lirong Wang; Han Han; Ren Cai; Xiaoyi Wu; Bai Xiao The prevailing cause of α-thalassemia in Southeast Asia is the presence of 3 deletion mutations in the α-globin genes (–SEA, –α 3.7 and –α 4.2 ). Current detection methods include gap polymerase chain...

...A.P. Gelpi The percentage of Hb S in hemolysates from 109 Saudi Arab males was found to range from 18–47%, with a mean of 33%, an obvious mode at 32–34% and clear skewing of the overall pattern toward lower values. A tentative explanation of this finding is the concurrence of the α-thalassemia...

... heterozygotes for Hb Hasharon and β -Thalassemia from 43 apparently unrelated families living in the province of Rovigo (northern Italy). Biosynthetic studies are also reported. The data strongly suggest the presence of an α -thalassemia-2 determinant closely linked to the α Hasharon -chain locus. Selective...

...P. Tabone; T. Henni; M. Belhani; P. Colonna; G. Verdier; J. Godet A case of Hb H disease from Algeria was studied at the genetic and molecular level in order to delineate the pattern of α-thalassemia in the Mediterranean population. The family study indicated that both parents had the hematological...

... which contained more than 0.5% Hb Bart’s. These findings suggest that elevated Hb Bart’s levels in the Algerian population are due to the presence of α-thalassemia. 4 08 1980 15 10 1980 27 2 2009 Acta haemat. 65: 240-246 (1981) Hemoglobin Bart s in Northern Algeria 7. Henni", D...

... in the blood for the remaining 2. The decrease in the relative synthesis of α-globin on erythroid cell maturation may relate to the molecular basis of α-thalassemia in the Middle East. 26 03 1980 25 04 1980 27 2 2009 © 1980 S. Karger AG, Basel 1980 Copyright / Drug Dosage / Disclaimer...

... studies and globin chain synthesis analysis (23 subjects). The α/ β ratio of 0.70 + 0.10 was the same as in obligate α -thalassemia -1 ( α -thal) carriers. Hb H inclusion bodies studies were found to be a reliable test for α -thal trait identification, resulting positive in approximately 70% of suspected...

... fragment. Mild hematological alterations were present. These data indicate that also in the Cuban population the α G Philadelphia locus is linked to a deletional α -thalassemia 27 09 1985 21 10 1985 25 2 2009 © 1985 S. Karger AG, Basel 1985 Copyright / Drug Dosage / Disclaimer...

...S. Daenen; A.L. Reese; F.K. Kutlar; T.H.J. Huiman Detailed hematological and fetal hemoglobin data as well as results from gene mapping analyses are reported for nine members of an Indonesian-Dutch family. An α -thalassemia-1 heterozygosity (Southeast Asian type) was present in five subjects...

... α -Thalassemia Acta haemat. 73: 181-182(1985) © 1985 S. Karger AG, Basel 0001-5792/85/0733-0181 $ 2.75/0 Priapism in Association with Sickle Cell Anemia in Saudi Arabia1 Baker Al-Awamy, Saud A. Taha, Mahtab A. Naeem Sickle Cell Anemia Group, King Faisal University, Dammam, Saudi Arabia Key Words...

...Hong-Wen Peng; Kong-Bung Choo; Chao-Hung Ho; Ming-Shyen Yen; Wan-Ying Liung; Chung-King Lin; Zaw-Ling Yang; Heung-Tat Ng; King-Nien Ching; Shou-Hwa Han In a gene mapping study on 217 newborn babies in Taiwan with α- and ζ-globin probes, we have observed 4 cases (1.84%) of α-thalassemia-2...

... comparable to those seen in patients with a homozygosity for the -29 mutation or with the combination of this β + -thalassemia and Hb S. An α-thalassemia-2 heterozygosity (-3.7 kb deletion) was present in 2 patients. Their hematological data were improved over those for the patients with four α globin genes...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. α-Gene deletion HbH disease α-Thalassemia Case Report Acta Haematol 1992;87:145-147...

... in the 20/20 group and the highest in the 3/3 group. Female SS patients with haplotypes 19/19 have higher Hb F levels than their male counterparts; the same was observed for the patients with the 19/3 haplotype combination but not for those with the 20/3 haplotype combination. A concomitant α-thalassemia-2...

... α-thal trait did not have severe recurrent infections and none had gallstones. The high frequencies of the Saudi Arabia/India βs haplotype and α-thalassemia trait contribute to the mild nature of SS disease among Kuwaiti Arabs comparable to that in eastern Saudi Arabia. Original Paper Acta Haematol...