The prognostic value of the Plasma Cell Synthesis Score (PCSS) has been tested in a group of 140 patients with multiple myeloma followed up from diagnosis to death. Calculation of PCSS, based on the regression coefficients obtained by multivariate regression analysis according to Cox’s model, was performed according to the formula:PCSS = [(serum β2mg (mg/l)/bone marrow plasma cells (%) × 1.609) + (M-component (g/dl)/bone marrow plasma cells (%)× 1.502)]×100. Substratification into three risk groups was performed as follows: low risk = PCSS more than 70; moderate risk = PCSS between 50 and 70; high risk = PCSS less than 50. Significant differences were found among the three stages regarding median survivals (p < 0.005), survival curves (p < 0.000000001), and response to therapy (p < 0.00001). A positive significant relationship was demonstrated between calculated PCSS and survival in the whole group (p < 0.000001). PCSS could be a good estimation of bone marrow plasma cell differentiation, and therefore could be a useful prognostic parameter in multiple myeloma.

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