We report a patient with an erythrocyte autoantibody in whose serum a broadly reactive antibody was transiently replaced by a monospecific autoanti-Jka. On preoperation evaluation, a 49-year-old man, who had never been transfused, exhibited both a positive antibody screen and a positive direct antiglobulin test. Although a broadly reactive antibody had been present 2 years earlier, only anti-Jka was found in the serum on preoperative testing. In contrast, an acid eluate prepared from the patient’s red cells at that time was reactive with all cells from a 10-cell panel – a finding consistent with the broadly reactive autoantibody noted earlier. Repeat testing of a sample obtained 1 week later revealed only a broadly reactive autoantibody in both serum and eluate. This patient is notable in two respects. He exhibited a rare autoantibody, monospecific anti-Jka, and the specificity of the autoantibody changed from broadly reactive when first detected to anti-Jka and then back to broadly reactive. Thus, antibodies directed against specific antigens, in the setting of autoimmune hemolytic anemia, may be part of the autoimmune process and not always alloantibodies.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.