Induced hyperglycemia in normal subjects increases α2-macroglobulin (α2M) activity and α2M concentration and reduces antithrombin III (ATIII) activity, while it does not affect ATIII plasma concentration. Hyperglycemia-determined variations in ATIII activity and α2M molecules are correlated in an inverse and parallel fashion. A compensatory role for the increase in α2M in the regulation of the coagulation system may be hypothesized. Moreover, these data provide evidence that hyperglycemia may decrease, directly, the biological function of some proteins and may influence the levels of some risk factors for the development of complications in diabetes.

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