The mechanism of inhibition of fibrin monomer polymerization was studied in a patient with primary amyloidosis. Thrombin and reptilase times of the patient’s purified fibrinogen (Fbg) were remarkably prolonged, and polymerization of the patient’s fibrin monomer was disturbed. Fbg-Bence Jones protein (BJP) complex was demonstrated by immunoelectrophoresis and sodium dodecyl sulfate-polyacrylamide gel electrophoresis on the patient’s purified Fbg. The patient’s BJP not only prolonged the thrombin time of normal Fbg but also inhibited the polymerization of normal fibrin monomer. These results suggested that in this patient fibrin monomer polymerization was inhibited by binding of BJP to Fbg.

Keywords:
Amyloidosis, Bence Jones protein, Fibrin monomer polymerization, Fibrinogen, Fibrinogen-Bence Jones protein complex, Thrombin time
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© 1989 S. Karger AG, Basel
1989
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