Using dried blood on filter paper, neonatal screening and mass-spectrometric analysis of hemoglobin variants were carried out in Osaka Prefecture, Japan. The following results emerged. (1) Of 140,597 newborns screened, 28 α (1/5,000) and 91 γ(1/1,500) chain variants were detected. (2) Of 65 γ chain variants examined, more than half (in 40 samples) were Hb F Yamaguchi (AγT 80 Asp→ Asn). This fact explains the high incidence of γ chain variants in the present study. (3) Two new γ chain variants, Hb F Fuchu (Gγ 21 Glu → Gln) and Hb F Minoo (Gγ72Glγ → Arg), were detected

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