Clinical, haematological and biochemical aspects of a new family with heterozygous haemoglobin Presbyterian [β108 (G 10) Asn→Lys] are described. It could be readily separated by isoelectric focusing, DEAE-cellulose chromatography and by cation exchange high-performance liquid chromatography (HPLC). The characterization of this mildly unstable haemoglobin was made by reverse-phase HPLC. This is the fourth family with Hb Presbyterian so far described.
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© 1986 S. Karger AG, Basel
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