In guinea pig bone marrow cultures with heterozygous α-thalassemic serum, 59Fe uptake values are elevated above iron values of cultures with serum of normal subjects. These results show that erythropoietin (EP) activity values in heterozygous α-thalassemia are comparable to those previously observed by ourselves in heterozygous β-thalassemia despite of the different Hb concentration in these thalassemic syndromes. This points to the existence of signals which regulate Ep synthesis independently of Hb levels.

Keywords:
Cell culture, Erythropoietin, In vitro 59Fe uptake, Thalassemia
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© 1986 S. Karger AG, Basel
1986
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